College of Life Sciences, Northwest University, Xi'an, Shaanxi, PR China.
Phytochemistry. 2010 Oct;71(14-15):1690-4. doi: 10.1016/j.phytochem.2010.06.019. Epub 2010 Jul 23.
The biosynthesis of the iridoid glucoside lamalbid in Lamium barbatum, a plant species in the Lamiaceae, was investigated by administrating (13)C-labeled intermediates of MVA and MEP pathways, respectively. The results demonstrated that [3,4,5-(13)C(3)]1-deoxy-D-xylulose 5-phosphate could be incorporated into lamalbid, whereas the incorporation of [2-(13)C(1)]mevalonolactone was not observed. Based on the (13)C labeling pattern of lamalbid and the incorporation data, we deduce that the iridoid glucoside in L. barbatum is biosynthesized through the MEP pathway, whereas the classic MVA pathway is not utilized.
我们通过分别施用 MVA 和 MEP 途径的 13C 标记中间产物，研究了唇形科植物夏枯草中裂环环烯醚萜苷类化合物毛兰素的生物合成途径。结果表明，[3,4,5-(13)C3]1-脱氧-D-木酮糖 5-磷酸可掺入毛兰素，而 [2-(13)C1]甲羟戊酸内酯则未被观察到掺入。基于毛兰素的 13C 标记模式和掺入数据，我们推断 L. barbatum 中的裂环环烯醚萜苷类化合物是通过 MEP 途径生物合成的，而不是经典的 MVA 途径。
