Schüürmann G
Bayer AG, Leverkusen, Federal Republic of Germany.
Ecotoxicol Environ Saf. 1991 Apr;21(2):227-33. doi: 10.1016/0147-6513(91)90024-j.
The recently derived log Kow (octanol/water partition coefficient in logarithmic form) increment for a nonterminal oxyethylene unit was used to calculate a quantitative structure-activity relationships for literature data on the acute crustacean toxicity of polyoxyethylene surfactants. The resulting log Kow regression parameters are between the corresponding values for nonpolar and polar narcosis, which supports an interpretation of the surfactants' aquatic toxicity on the basis of another distinct mode of action. Furthermore, a comparison with calculated water solubility data indicates that for log Kow greater than 5 an aquatic toxicity decrease due to a solubility limit is expected, which gets support from two other sets on toxicity data of nonyl phenol polyethoxylates.
最近推导出的非末端氧化乙烯单元的对数辛醇/水分配系数（log Kow）增量，用于计算有关聚氧乙烯表面活性剂对甲壳类动物急性毒性的文献数据的定量构效关系。所得的log Kow回归参数介于非极性和极性麻醉的相应值之间，这支持了基于另一种不同作用模式对表面活性剂水生毒性的解释。此外，与计算出的水溶性数据进行比较表明，对于log Kow大于5的情况，预计由于溶解度限制会导致水生毒性降低，这得到了壬基酚聚乙氧基化物的另外两组毒性数据的支持。
