Pulmonary and Allergy Disease Paediatric Unit, G Gaslini Institute, Genoa, Italy.
Arch Dis Child. 2010 Dec;95(12):979-84. doi: 10.1136/adc.2009.163667. Epub 2010 Jul 23.
Despite the therapeutic efficacy of the anti-IgE monoclonal antibody, the role of IgE in allergic asthma is still a matter of debate. This may be mostly relevant in childhood, where a wide range of total serum (s) IgE levels is often detected.
To evaluate whether the relationships between total or allergen-specific sIgE levels and the clinical markers of allergic inflammation and the pulmonary function values might be affected by the demographic characteristics of the patients or by the presence of multiple sensitisations to allergens.
64 asthmatic children sensitised to house dust mites (HDM) were evaluated. The role of age, sex and multiple sensitisations was evaluated by multiple regression model (MRM) analysis.
Total and HDM-specific sIgE levels (Log) showed similar moderate-to-strong correlations with exhaled nitric oxide (FENO) and blood eosinophilia (Log) (p<0.0001) but not with forced vital capacity, forced expiratory volume in 1 s (FEV(1)), %FEV(1) change after salbutamol. The positive associations between total sIgE levels and Log FENO levels or Log blood eosinophilia were also detected by MRM analysis. Age brought a negative, although limited, contribution to FENO levels and blood eosinophilia (p<0.043). Positive similar associations were also detected between HDM-specific sIgE levels and FENO levels or blood eosinophilia; however, no significant contribution of age or of other covariates was detected.
In childhood allergic asthma, total and HDM-specific sIgE levels are tightly linked to markers of allergic inflammation but not to pulmonary functions. These relationships are weakly affected by age but not by sex or by the presence of multiple sensitisations.
尽管抗 IgE 单克隆抗体具有治疗功效，但 IgE 在过敏性哮喘中的作用仍存在争议。这在儿童中可能更为相关，因为在儿童中经常检测到广泛的总血清（s）IgE 水平。
评估总 IgE 或过敏原特异性 sIgE 水平与过敏性炎症的临床标志物和肺功能值之间的关系是否可能受到患者的人口统计学特征或对过敏原的多重致敏的影响。
评估了 64 名对屋尘螨（HDM）敏感的哮喘儿童。通过多元回归模型（MRM）分析评估年龄、性别和多重致敏的作用。
总 IgE 和 HDM 特异性 sIgE 水平（Log）与呼出气一氧化氮（FENO）和血嗜酸性粒细胞计数（Log）呈相似的中度至强相关性（p<0.0001），但与用力肺活量、用力呼气量在 1 秒内（FEV（1））、沙丁胺醇后 FEV（1）%变化无关。MRM 分析还发现总 sIgE 水平与 Log FENO 水平或 Log 血嗜酸性粒细胞计数之间存在正相关关系。年龄对 FENO 水平和血嗜酸性粒细胞计数有负向影响，但影响有限（p<0.043）。还检测到 HDM 特异性 sIgE 水平与 FENO 水平或血嗜酸性粒细胞计数之间存在相似的正相关关系；然而，未检测到年龄或其他协变量的显著贡献。
在儿童过敏性哮喘中，总 IgE 和 HDM 特异性 sIgE 水平与过敏性炎症标志物密切相关，但与肺功能无关。这些关系受年龄影响较弱，但不受性别或多重致敏的影响。
