de Bot Cindy M A, Moed Heleen, Bindels Patrick J E, van Wijk Roy Gerth, Berger Marjolein Y, de Groot Hans, de Jongste Johannes C, van der Wouden Johannes C
Department of General Practice, Erasmus MC-University Medical Center, Rotterdam, The Netherlands.
Prim Care Respir J. 2013 Mar;22(1):44-50. doi: 10.4104/pcrj.2013.00009.
Allergic rhinitis (AR) and asthma are both inflammatory diseases and are often associated. Relationships between fractional exhaled nitric oxide (FeNO) and asthma, atopy, and quality of life have been shown.
This study aimed to determine whether FeNO in children with AR (n=158) or combined AR and asthma (n=93) was associated with clinical symptoms, house dust mite (HDM)-specific IgE, and rhinitis-specific quality of life, both cross-sectionally and longitudinally.
Children with AR aged 6-18 years (n=251) in primary care were assessed for FeNO, nasal symptom scores, asthma symptom scores, quality of life, and HDM-specific IgE at baseline and 2 years later.
We found similarly elevated FeNO in children with only AR and in those with combined AR and asthma. No correlations were found between FeNO and nasal or asthma symptoms and rhinitis-related quality of life. Longitudinal correlations were strongest for HDM-specific IgE (r=0.91, p<0.0001).
FeNO was similar in a selected group of children with AR with and without asthma in primary care and was unrelated to symptoms or quality of life in both groups. FeNO is unlikely to be a useful biomarker of the clinical severity of upper or lower airway disease in primary care.
变应性鼻炎（AR）和哮喘均为炎症性疾病，且常相互关联。已证实呼出气一氧化氮分数（FeNO）与哮喘、特应性及生活质量之间存在关联。
本研究旨在横断面及纵向确定AR患儿（n = 158）或AR合并哮喘患儿（n = 93）的FeNO是否与临床症状、屋尘螨（HDM）特异性IgE及鼻炎特异性生活质量相关。
对初级保健机构中251例6至18岁的AR患儿在基线及2年后评估其FeNO、鼻部症状评分、哮喘症状评分、生活质量及HDM特异性IgE。
我们发现仅患AR的患儿与AR合并哮喘的患儿FeNO同样升高。未发现FeNO与鼻部或哮喘症状及鼻炎相关生活质量之间存在相关性。HDM特异性IgE的纵向相关性最强（r = 0.91，p < 0.0001）。
在初级保健机构中，一组有或无哮喘的AR患儿的FeNO相似，且与两组的症状或生活质量均无关。FeNO不太可能成为初级保健中上、下气道疾病临床严重程度的有用生物标志物。
