短非编码核 RNA 对可变剪接的调控。
Regulation of alternative splicing by short non-coding nuclear RNAs.
机构信息
University of Kentucky, Molecular and Cellular Biochemistry, South Limestone, Lexington, KY, USA.
出版信息
RNA Biol. 2010 Jul-Aug;7(4):480-5. doi: 10.4161/rna.7.4.12746. Epub 2010 Jul 1.
Abstract
Recent results from deep-sequencing and tiling array studies indicated the existence of a large number of short, metabolically stable, non-coding RNAs. Some of these short RNAs derive from known RNA classes like snoRNA or tRNAs. There are intriguing similarities between short non-coding nuclear RNAs and oligonucleotides used to change alternative splicing events, which usually target a disease-relevant RNA. We review the current knowledge of this emerging class of RNAs and discuss evidence that some of these short RNAs could function in alternative splice site selection.
摘要
最近的深度测序和平铺阵列研究结果表明，存在大量短的、代谢稳定的非编码 RNA。其中一些短 RNA 来自已知的 RNA 类别，如 snoRNA 或 tRNA。短非编码核 RNA 与用于改变剪接事件的寡核苷酸之间存在有趣的相似性，这些寡核苷酸通常针对与疾病相关的 RNA。我们回顾了这一新兴 RNA 类别的现有知识，并讨论了一些短 RNA 可能在选择剪接位点中发挥作用的证据。
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