Department of Physiology and Biophysics, University of California at Irvine, Irvine, California 92697, USA.
Pediatr Res. 2010 Nov;68(5):399-404. doi: 10.1203/PDR.0b013e3181f2e836.
Little is known about the effect of physical activity in early life on subsequent growth and regulation of inflammation. We previously reported that exposure of muscles in growing rats to IL-6 results in decreased muscle growth apparently because of a state of resistance to growth factors such IGF-I and that running exercise could ameliorate this growth defect. Herein, we hypothesized that increased activity, for a brief period during neonatal life, would pattern the adult rat toward a less inflammatory phenotype. Neonatal rats were induced to move about their cage for brief periods from d 5 to d 15 postpartum. Additional groups were undisturbed controls (CONs) and handled (HAND). Subgroups of rats were sampled at the age of 30 and 65 d. Relative to CON and HAND groups, the neonatal exercise (EX) group demonstrated a decrease in circulating levels of TNFα, IL-6, and IL-1β in adulthood, primarily in male rats. In addition, adult male EX rats had lower body mass and increased skeletal muscle mass suggesting a leaner phenotype. The results of this study suggest that moderate increases in activity early in life can influence the adult toward a more healthy phenotype with regard to inflammatory mediators and relative muscle mass.
关于生命早期的身体活动对后续生长和炎症调节的影响知之甚少。我们之前的研究报告表明，在生长中的大鼠的肌肉中暴露于 IL-6 会导致肌肉生长减少，显然是因为处于对 IGF-I 等生长因子的抵抗状态，而跑步运动可以改善这种生长缺陷。在此，我们假设在新生儿期进行短暂的增加活动会使成年大鼠形成一种炎症表型。从产后第 5 天到第 15 天，新生大鼠被诱导在其笼子里短暂活动。其他组为未处理对照（CON）和处理（HAND）组。在 30 天和 65 天时，对大鼠的亚组进行采样。与 CON 和 HAND 组相比，新生运动（EX）组在成年后循环中 TNFα、IL-6 和 IL-1β 的水平降低，主要在雄性大鼠中。此外，成年雄性 EX 大鼠的体重较低，骨骼肌质量增加，表明表型更瘦。这项研究的结果表明，生命早期适度增加活动可以使成年大鼠在炎症介质和相对肌肉质量方面朝着更健康的表型发展。
