Denoyer M, Sallanon M, Buda C, Delhomme G, Dittmar A, Jouvet M
Département de Médecine Expérimentale, INSERM U 52, CNRS-UA, Université Claude Bernard, Lyon, France.
Exp Brain Res. 1991;84(2):326-34. doi: 10.1007/BF00231453.
Electroencephalogram, caudate nucleus temperature (Tc), ear skin temperature (Te) as well as cerebral blood flow (CBF) measured by a thermal clearance method, were recorded simultaneously and continuously in cats. After baseline recording in which we confirmed the increase of Tc during paradoxical sleep (PS), neuronal cell bodies of the mesencephalic reticular formation and/or the posterior hypothalamus (PH) were destroyed with ibotenic acid. Only PH lesions were followed by either a suppression of the increase or even a decrease of Tc during PS while Te variations were not modified. The decrease in CBF, which was always associated with Tc increase, was suppressed after the PH lesion. These results led us to the conclusion that the increase of Tc at the onset of PS is due to a decrease in CBF. Furthermore, it may be hypothesized that the decrease in CBF depend upon an active vasoconstriction process originating in the PH.
在猫身上同时连续记录脑电图、尾状核温度（Tc）、耳部皮肤温度（Te）以及通过热清除法测量的脑血流量（CBF）。在进行基线记录以确认在异相睡眠（PS）期间Tc升高后，用鹅膏蕈氨酸损毁中脑网状结构和/或下丘脑后部（PH）的神经元细胞体。仅损毁PH后，PS期间Tc升高受到抑制甚至降低，而Te变化未改变。总是与Tc升高相关的CBF降低在损毁PH后受到抑制。这些结果使我们得出结论：PS开始时Tc升高是由于CBF降低。此外，可以推测CBF降低取决于源自PH的主动血管收缩过程。
