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一种简便的一锅法合成 1-芳基吡唑并[3,4-d]嘧啶-4-酮的方法。

A facile one-pot synthesis of 1-arylpyrazolo[3,4-d]pyrimidin-4-ones.

机构信息

College of Chemistry and Materials Engineering, Wenzhou Universtity, Wenzhou 325035, China.

出版信息

Molecules. 2010 Apr 27;15(5):3079-86. doi: 10.3390/molecules15053079.

DOI:10.3390/molecules15053079
PMID:20657465
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6263351/
Abstract

One pot synthesis of 1-arylpyrazolo[3,4-d]pyrimidin-4-ones by the reaction of 5-amino-N-substituted-1H-pyrazole-4-carbonitrile with different lower aliphatic acids in the presence of POCl(3) has been developed. The structures of all the title compounds have been confirmed by IR, (1)H-NMR, (13)CNMR, and elemental analyses. Moreover, the structures of one of these compounds, 2c, was confirmed by single-crystal X-ray diffraction.

摘要

一锅法合成 1-芳基吡唑并[3,4-d]嘧啶-4-酮，由 5-氨基-N-取代-1H-吡唑-4-甲腈与不同的低级脂肪酸在 POCl(3)的存在下反应得到。所有标题化合物的结构均通过 IR、(1)H-NMR、(13)C-NMR 和元素分析得到确认。此外，其中一个化合物 2c 的结构通过单晶 X 射线衍射得到确认。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31bb/6263351/4dceee3c6a30/molecules-15-03079-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31bb/6263351/6eecbf3c9cb8/molecules-15-03079-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31bb/6263351/9eed6d75d3ae/molecules-15-03079-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31bb/6263351/3c27c2a175b1/molecules-15-03079-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31bb/6263351/4dceee3c6a30/molecules-15-03079-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31bb/6263351/6eecbf3c9cb8/molecules-15-03079-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31bb/6263351/9eed6d75d3ae/molecules-15-03079-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31bb/6263351/3c27c2a175b1/molecules-15-03079-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31bb/6263351/4dceee3c6a30/molecules-15-03079-g001.jpg

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