A facile one-pot synthesis of 1-arylpyrazolo[3,4-d]pyrimidin-4-ones.

One pot synthesis of 1-arylpyrazolo[3,4-d]pyrimidin-4-ones by the reaction of 5-amino-N-substituted-1H-pyrazole-4-carbonitrile with different lower aliphatic acids in the presence of POCl(3) has been developed. The structures of all the title compounds have been confirmed by IR, (1)H-NMR, (13)CNMR, and elemental analyses. Moreover, the structures of one of these compounds, 2c, was confirmed by single-crystal X-ray diffraction.