黄酮类化合物作为大鼠肝脏胞质谷胱甘肽S-转移酶的抑制剂
Flavonoids as inhibitors of rat liver cytosolic glutathione S-transferase.
作者信息
Merlos M, Sanchez R M, Camarasa J, Adzet T
机构信息
Laboratory of Pharmacology and Pharmacognosy, School of Pharmacy, University of Barcelona, Spain.
出版信息
Experientia. 1991 Jun 15;47(6):616-9. doi: 10.1007/BF01949888.
The inhibitory potencies of different flavonoids for rat liver cytosolic glutathione S-transferase activity varied over 30-fold, depending on the pattern of hydroxylation, the presence of a C-2, C-3 double bond and the substitution of a hydroxyl group with a sugar moiety. Kinetic inactivation studies of the enzyme with the inhibitor quercetin revealed a non-competitive profile versus both glutathione and 1-chloro-2,4-dinitrobenzene.
不同类黄酮对大鼠肝脏胞质谷胱甘肽S-转移酶活性的抑制效力变化超过30倍，这取决于羟基化模式、C-2、C-3双键的存在以及羟基被糖基部分取代的情况。用抑制剂槲皮素对该酶进行的动力学失活研究表明，相对于谷胱甘肽和1-氯-2,4-二硝基苯，其呈现非竞争性特征。
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