黄酮类化合物和过渡金属阳离子对抗原诱导人嗜碱性粒细胞释放组胺的影响。
Effects of flavonoids and transitional metal cations on antigen-induced histamine release from human basophils.
作者信息
Middleton E, Drzewiecki G
出版信息
Biochem Pharmacol. 1982 Apr 1;31(7):1449-53. doi: 10.1016/0006-2952(82)90044-2.
PMID:6178414
Abstract
Structure-activity relationship studies have been performed on the inhibition of antigen-induced histamine release from human basophils by various naturally occurring flavonoids. Quercetin was the most active compound. Of the transitional metal ions, Cu2+ most effectively blocked the inhibitory activity of quercetin, possibly through a chelation mechanism.
摘要
已经对各种天然存在的黄酮类化合物抑制抗原诱导的人嗜碱性粒细胞组胺释放进行了构效关系研究。槲皮素是最具活性的化合物。在过渡金属离子中，Cu2+最有效地阻断了槲皮素的抑制活性，可能是通过螯合机制。
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