Division of Fetal-Maternal Medicine, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge, UK.
Prenat Diagn. 2010 Sep;30(9):873-8. doi: 10.1002/pd.2578.
We sought to define the relationship between first trimester fetal growth, pregnancy-associated plasma protein A (PAPP-A) levels and birthweight.
Two-hundred and one women with repeat first trimester crown-rump length (CRL) measurements were included. In 194, the first trimester PAPP-A value was known and in 169 there was complete data including birthweight. Fetal growth curves were derived using functional linear discriminant analysis (FLDA) and growth compared between those with < 10th percentile, 10th to 90th and > 90th percentile PAPP-A multiple of median (MoM) levels and birthweight percentiles.
Median maternal age was 35 years, gestation at PAPP-A sampling and of first scan was 11 weeks. Median delivery gestation was 40 weeks and birthweight 3425 g. There was no association between first trimester fetal CRL growth and either PAPP-A MoM percentile or birthweight percentile. There was a significant positive correlation between PAPP-A MoM and birthweight percentile (p = 0.0004).
First trimester fetal growth rate is not related to birthweight percentile or first trimester PAPP-A levels. Irrespective of gestation, a low PAPP-A is associated with delivery of a smaller baby, and a high PAPP-A with a larger baby.
我们旨在确定孕早期胎儿生长、妊娠相关血浆蛋白 A（PAPP-A）水平与出生体重之间的关系。
共纳入 210 例具有重复孕早期头臀长（CRL）测量值的女性。在 194 例中，已知孕早期 PAPP-A 值，在 169 例中，包括出生体重在内的完整数据。使用函数线性判别分析（FLDA）得出胎儿生长曲线，并比较 PAPP-A 中位数倍数（MoM）水平和出生体重百分位数<第 10 百分位、第 10 至 90 百分位和>第 90 百分位的胎儿生长情况。
母亲的中位年龄为 35 岁，PAPP-A 采样和首次扫描时的孕龄为 11 周。中位分娩孕龄为 40 周，出生体重为 3425g。孕早期胎儿 CRL 生长与 PAPP-A MoM 百分位或出生体重百分位之间均无关联。PAPP-A MoM 与出生体重百分位呈显著正相关（p=0.0004）。
孕早期胎儿生长速度与出生体重百分位或孕早期 PAPP-A 水平无关。无论孕龄如何，低 PAPP-A 与分娩较小的婴儿有关，而高 PAPP-A 与分娩较大的婴儿有关。
