Kuz'min V S, Rozenshtraukh L V
Kardiologiia. 2010;50(7):49-61.
In this review we discuss mechanisms of antiarrhythmic and adverse proarrhythmic action of class III drugs. Special attention is given to ionic currents and channels which determine specific features of their effects (IKr, IKa, IKur). We consider general patterns of changes of bioelectrical activity in atria and ventricles leading to development of arrhythmias or stabilization of rhythm. We also discuss value of QT interval as predictor of torsade de pointes. Perspectives and limitations of development of novel class III antiarrhythmic drugs are discussed as well. We present consideration of efficacy and mechanisms of action of such compounds as dronedarone and vernacalant suggested for termination of atrial fibrillation and maintenance of sinus rhythm. Special attention is given to RG 2 - a novel compound with class III activity.
在本综述中，我们讨论了Ⅲ类药物的抗心律失常作用机制及致心律失常不良反应机制。特别关注了决定其效应（快速激活延迟整流钾电流、缓慢激活延迟整流钾电流、超快速激活延迟整流钾电流）特异性的离子电流和通道。我们考虑了心房和心室生物电活动变化导致心律失常发生或节律稳定的一般模式。我们还讨论了QT间期作为尖端扭转型室性心动过速预测指标的价值。此外，还讨论了新型Ⅲ类抗心律失常药物研发的前景与局限性。我们介绍了对用于终止心房颤动和维持窦性心律的药物（如决奈达隆和维纳卡兰）的疗效及作用机制的考量。特别关注了RG 2——一种具有Ⅲ类活性的新型化合物。
