University of Oxford, Oxford, UK.
Dis Esophagus. 2011 Feb;24(2):79-85. doi: 10.1111/j.1442-2050.2010.01096.x.
Bulimia nervosa and other eating disorders have been on the increase for the past half century. Self-induced vomiting is often practiced as a method of weight control in these patients, potentially causing acidic damage to the esophagus of the kind observed in cases of gastroesophageal reflux disease. To ascertain whether patients suffering from bulimia nervosa had an increased rate of reflux-related symptoms, potentially placing them at risk of developing sequelae such as Barrett's esophagus and esophageal adenocarcinoma, a literature review was performed via searches of databases including PubMed, Medline, OVID and PsycINFO and a recursive search of the literature. The search terms were: bulimia nervosa; reflux; esophageal adenocarcinoma; Barrett's esophagus; eating disorders; oral; dental; complications. Several case reports were identified detailing the occurrence of an esophageal tumor in patients with a history of bulimia. This was supported to some degree by studies detailing higher incidences of reflux symptoms in eating disordered patients compared to controls but there was large variability in study design, quality and results. From these results an association is suggested as possible but is far from being proved conclusively. Further investigation is required using larger patient groups, better study design controlling for confounding factors and symptom characterisation.
在过去的半个世纪里，神经性贪食症和其他饮食失调症的发病率一直在上升。这些患者经常采用自我诱导呕吐的方法来控制体重，这可能导致食管出现类似于胃食管反流病的酸性损伤。为了确定患有神经性贪食症的患者是否有更高的反流相关症状发生率，从而有可能患上巴雷特食管和食管腺癌等后遗症，我们通过在 PubMed、Medline、OVID 和 PsycINFO 等数据库中进行检索，并对文献进行递归搜索，进行了文献回顾。检索词为：神经性贪食症；反流；食管腺癌；巴雷特食管；饮食失调；口腔；牙科；并发症。有几份病例报告详细描述了有贪食症病史的患者发生食管肿瘤的情况。这在一定程度上得到了一些研究的支持，这些研究详细描述了与对照组相比，饮食失调患者的反流症状发生率更高，但研究设计、质量和结果存在很大的变异性。从这些结果中可以看出，这种关联是可能的，但还远未得到确凿的证明。需要使用更大的患者群体、更好的研究设计来控制混杂因素和症状特征，进一步进行调查。
