Centre de Recerca en Sanitat Animal (CReSA), UAB-IRTA, Campus de la Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Spain.
Virus Res. 2010 Dec;154(1-2):123-32. doi: 10.1016/j.virusres.2010.07.017. Epub 2010 Jul 24.
Porcine reproductive and respiratory syndrome virus (PRRSV) is one of the most costly pathogens for the swine industry. Since its emergence some 20 years ago, much has been learned about the immunobiology of PRRSV. Although vaccines are available, they do not provide full and universal protection against PRRSV infection. In the present review, current knowledge on the virus's immunobiology will be discussed including: role of viral receptors, innate immune response to the virus, regulation of the immune response by PRRSV, and the characteristics and role of adaptive immunity. In addition, some hypotheses for future research in this area are presented.
猪繁殖与呼吸综合征病毒（PRRSV）是养猪业最昂贵的病原体之一。自 20 年前出现以来，人们对 PRRSV 的免疫生物学有了更多的了解。尽管有疫苗可用，但它们并不能提供针对 PRRSV 感染的完全和普遍保护。在本综述中，将讨论当前对该病毒免疫生物学的认识，包括：病毒受体的作用、对病毒的先天免疫反应、PRRSV 对免疫反应的调节以及适应性免疫的特征和作用。此外，还提出了该领域未来研究的一些假设。
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