CD11c 表达在套细胞淋巴瘤诊断中的作用。

The role of CD11c expression in the diagnosis of mantle cell lymphoma.

机构信息

Dept. of Pathology and Laboratory Medicine, Emory University Hospital, Atlanta, GA 30322, USA.

出版信息

Am J Clin Pathol. 2010 Aug;134(2):271-7. doi: 10.1309/AJCPOGCI3DAXVUMI.

PMID:20660331

Abstract

Flow cytometric immunophenotyping (FCI) aids in the differentiation of chronic lymphocytic leukemia (CLL) from mantle cell lymphoma (MCL); however, overlapping phenotypes may occur. CD11c expression has been reported in up to 90% of CLL cases but has rarely been reported in MCL. Whether CD11c can be used to exclude MCL has not been directly addressed. FCI reports were reviewed for 90 MCL cases (44 patients) and 355 CLL/small lymphocytic lymphoma (SLL) cases (158 patients). MCL cases were confirmed by cyclin D1 immunoreactivity and/or t(11;14) detection by karyotyping or fluorescence in situ hybridization. Cases with typical MCL immunophenotypes did not express CD11c. The 2 MCL cases displaying dim CD11c positivity (2 of 44 patients) expressed other markers not typical of MCL. CD11c was detected in 96 (27.0%) of 355 cases of CLL/SLL representing 53 of 158 patients. CD11c expression is rare in MCL and may aid in differentiation of CD5+ B-cell neoplasms, particularly when small samples limit further ancillary testing.

摘要

流式细胞免疫表型分析（FCI）有助于区分慢性淋巴细胞白血病（CLL）和套细胞淋巴瘤（MCL）；然而，两种疾病的表型可能会重叠。已有高达 90%的 CLL 病例中报告了 CD11c 的表达，但在 MCL 中很少有报道。CD11c 是否可用于排除 MCL 尚未得到直接解决。我们对 90 例 MCL 病例（44 名患者）和 355 例 CLL/小淋巴细胞淋巴瘤（SLL）病例（158 名患者）的 FCI 报告进行了回顾。通过 cyclin D1 免疫反应性和/或通过核型分析或荧光原位杂交检测 t（11；14）来确认 MCL 病例。具有典型 MCL 免疫表型的病例不表达 CD11c。2 例显示弱 CD11c 阳性的 MCL 病例（44 例患者中的 2 例）表达了其他非典型 MCL 的标志物。在 355 例 CLL/SLL 病例中检测到 CD11c（158 例患者中的 96 例）。CD11c 的表达在 MCL 中较为罕见，可能有助于区分 CD5+ B 细胞肿瘤，特别是当样本量有限限制了进一步的辅助检测时。