Zverina Eduard
Univerzita Karlova v Praze, 1. lékarská fakulta, Klinika ORL a chirurgie hlavy a krku FNM.
Cas Lek Cesk. 2010;149(6):269-76.
Acoustic neuroma, properly called vestibular schwannoma, arises from the Schwann cells of the vestibular transitional zone of the vestibulocochlear nerve as the most frequent tumour of the posterior fossa. Its incidence is estimated at 1.2 vestibular schwannoma per a population of 100,000/year. As to size, vestibular schwannoma is classified into grades I to IV. Its benign variety threatens the patient with hearing and balance impairment; uncontrolled growth can lead to death. About one third of small vestibular schwannoma show hardly any growth, the larger ones grow aggressively. The author's conclusion is based on 33 years of experience with hundreds of surgically treated vestibular schwannoma (now at the ENT Department of Head and Neck Surgery, CU 1st Medical Faculty and FN Teaching Hospital, Prague Motol). Three different therapeutic strategies are currently used: 1. Wait and rescan--close follow-up with regular MRI and hearing tests. Growing tumours require active intervention. 2. Stereoradio-surgery using the Leksell gamma knife is a suitable option for small tumours (grades I and II). Irradiation for larger vestibular schwannoma is decreasingly efficacious. 3. Microsurgery with intraoperative monitoring of facial and acoustic nerve function offers scope for radical removal of vestibular schwannoma of any size (grades I-IV) and for the preservation of facial nerve function and, of late, hearing, too. The larger the tumour, the more difficult it is. The demanding nature of microsurgery requires the patients' concentration in special centres with neurosurgical and ENT cooperation. The worst results are achieved with only a partial resection and follow-up stereoradiosurgical treatment. Secondary microsurgery can hardly prevent the patient's disability.
听神经瘤,正确名称为前庭神经鞘瘤,起源于前庭蜗神经前庭过渡区的施万细胞,是后颅窝最常见的肿瘤。其发病率估计为每年每10万人中有1.2例前庭神经鞘瘤。至于大小,前庭神经鞘瘤分为I至IV级。其良性类型会威胁患者的听力和平衡功能;不受控制的生长可能导致死亡。约三分之一的小型前庭神经鞘瘤几乎不生长,较大的则生长迅速。作者的结论基于33年对数百例接受手术治疗的前庭神经鞘瘤的经验(目前在布拉格莫托尔市查理大学第一医学院和FN教学医院头颈外科耳鼻喉科)。目前使用三种不同的治疗策略:1. 等待并重新扫描——通过定期的MRI和听力测试进行密切随访。肿瘤生长时需要积极干预。2. 使用Leksell伽玛刀进行立体定向放射外科手术是小型肿瘤(I级和II级)的合适选择。对较大的前庭神经鞘瘤进行放射治疗效果越来越差。3. 术中监测面神经和听神经功能的显微手术为彻底切除任何大小(I-IV级)的前庭神经鞘瘤以及保留面神经功能,后期还可保留听力提供了空间。肿瘤越大,手术难度越大。显微手术要求较高,需要患者在有神经外科和耳鼻喉科合作的特殊中心集中治疗。仅进行部分切除并随后进行立体定向放射外科治疗的效果最差。二次显微手术很难防止患者致残。