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前庭神经鞘瘤显微手术的并发症

Complications of microsurgery of vestibular schwannoma.

作者信息

Betka Jan, Zvěřina Eduard, Balogová Zuzana, Profant Oliver, Skřivan Jiří, Kraus Josef, Lisý Jiří, Syka Josef, Chovanec Martin

机构信息

Department of Otorhinolaryngology, Head and Neck Surgery, 1st Faculty of Medicine, Faculty Hospital Motol, Charles University in Prague, V Uvalu 84, Prague 5, 150 06 Prague, Czech Republic.

Department of Otorhinolaryngology, Head and Neck Surgery, 1st Faculty of Medicine, Faculty Hospital Motol, Charles University in Prague, V Uvalu 84, Prague 5, 150 06 Prague, Czech Republic ; Department of Auditory Neuroscience, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Videnska 1083, Prague 4, 142 20 Prague, Czech Republic.

出版信息

Biomed Res Int. 2014;2014:315952. doi: 10.1155/2014/315952. Epub 2014 May 28.

Abstract

BACKGROUND

The aim of this study was to analyze complications of vestibular schwannoma (VS) microsurgery.

MATERIAL AND METHODS

A retrospective study was performed in 333 patients with unilateral vestibular schwannoma indicated for surgical treatment between January 1997 and December 2012. Postoperative complications were assessed immediately after VS surgery as well as during outpatient followup.

RESULTS

In all 333 patients microsurgical vestibular schwannoma (Koos grade 1: 12, grade 2: 34, grade 3: 62, and grade 4: 225) removal was performed. The main neurological complication was facial nerve dysfunction. The intermediate and poor function (HB III-VI) was observed in 124 cases (45%) immediately after surgery and in 104 cases (33%) on the last followup. We encountered disordered vestibular compensation in 13%, permanent trigeminal nerve dysfunction in 1%, and transient lower cranial nerves (IX-XI) deficit in 6%. Nonneurological complications included CSF leakage in 63% (lateral/medial variant: 99/1%), headache in 9%, and intracerebral hemorrhage in 5%. We did not encounter any case of meningitis.

CONCLUSIONS

Our study demonstrates that despite the benefits of advanced high-tech equipment, refined microsurgical instruments, and highly developed neuroimaging technologies, there are still various and significant complications associated with vestibular schwannomas microsurgery.

摘要

背景

本研究旨在分析前庭神经鞘瘤(VS)显微手术的并发症。

材料与方法

对1997年1月至2012年12月间333例因手术治疗而收治的单侧前庭神经鞘瘤患者进行回顾性研究。术后并发症在VS手术后及门诊随访期间进行评估。

结果

对所有333例患者均实施了显微手术切除前庭神经鞘瘤(库斯分级1级:12例,2级:34例,3级:62例,4级:225例)。主要神经并发症为面神经功能障碍。术后即刻观察到124例(45%)出现中度及重度功能障碍(HB III - VI级),末次随访时为104例(33%)。我们发现13%的患者存在前庭代偿紊乱,1%的患者出现永久性三叉神经功能障碍,6%的患者出现短暂性低位颅神经(IX - XI)功能缺损。非神经并发症包括63%的患者发生脑脊液漏(外侧/内侧型:99/1%),9%的患者出现头痛,5%的患者发生脑内出血。未出现任何脑膜炎病例。

结论

我们的研究表明,尽管先进的高科技设备、精细的显微手术器械和高度发达的神经影像技术带来了诸多益处,但前庭神经鞘瘤显微手术仍存在各种严重并发症。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b14b/4058457/43eda64feb70/BMRI2014-315952.001.jpg

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