Taylor Barbara, Tofler Geoffrey, Morel-Kopp Marie-Christine, Carey Helen, Carter Torren, Elliott Margaret, Dailey Colette, Villata Luke, Ward Christopher, Woodward Mark, Schenck Karl
Sydney Dental Hospital, Surry Hills, Sydney, NSW, Australia.
Eur J Oral Sci. 2010 Aug;118(4):350-6. doi: 10.1111/j.1600-0722.2010.00748.x.
Observational studies indicate that chronic periodontal disease is associated with adverse cardiovascular outcomes. The aim of this study was to determine whether initial periodontal treatment has a beneficial effect on systemic markers of inflammation and cardiovascular risk. One hundred and thirty-six adults with chronic periodontitis were allocated to either intervention or control groups in a 3-month randomized controlled intervention study. The intervention group received initial periodontal treatment, whereas the control group did not receive that treatment until after the study. Blood levels of cardiovascular risk factors, and of hematological, inflammatory, and metabolic markers, were measured at the beginning and the end of the study, and differences were calculated. Fibrinogen level was the primary outcome measure. Data for 61 persons in the intervention group and for 64 persons in the control group were available for statistical analysis. Compared with the control group, the intervention group showed a non-significant trend for a lower fibrinogen level. Significant increases in hemoglobin and hematocrit were seen after treatment, showing that initial periodontal treatment, a relatively simple and cost-effective intervention, has systemic effects.
观察性研究表明，慢性牙周病与不良心血管结局相关。本研究的目的是确定初始牙周治疗是否对全身炎症标志物和心血管风险有有益影响。在一项为期3个月的随机对照干预研究中，136名患有慢性牙周炎的成年人被分配到干预组或对照组。干预组接受初始牙周治疗，而对照组在研究结束后才接受该治疗。在研究开始和结束时测量心血管危险因素以及血液学、炎症和代谢标志物的血液水平，并计算差异。纤维蛋白原水平是主要结局指标。干预组61人和对照组64人的数据可用于统计分析。与对照组相比，干预组的纤维蛋白原水平有降低的趋势，但无统计学意义。治疗后血红蛋白和血细胞比容显著增加，表明初始牙周治疗作为一种相对简单且经济有效的干预措施具有全身效应。
