Department of Periodontics and Oral Medicine, College & Hospital of Stomatology, Guangxi Medical University, No. 22, Shuangyong Road, Qingxiu District, Nanning, 530021, Guangxi, China.
Guangxi Key Laboratory of Oral and Maxillofacial Rehabilitation and Reconstruction, Nanning, China.
BMC Oral Health. 2024 Jun 14;24(1):692. doi: 10.1186/s12903-024-04433-0.
Cardiovascular disease (CVD) is the leading cause of mortality in the world. Patients with periodontitis have a higher risk of CVD, although a causal relationship between these conditions remains unclear. Non-surgical periodontal therapy (NSPT) is able to control inflammation at local and systemic levels. This study aimed to analyze the effect of NSPT on CVD risk markers.
Four electronic databases were searched from their inception to April 1, 2023, to identify and select articles without any language restrictions. Eleven CVD-related markers (e.g., C-reactive protein [CRP], Interleukin-6 [IL-6]) were selected. Meta-analyses were performed using random and fixed effect models. The differences were expressed as weighted mean differences (WMD) and 95% confidence interval (95% CI).
From 1353 studies, twenty-one randomized controlled clinical trials were included in the meta-analysis. Results showed a significant decrease in CRP, IL-6, and systolic blood pressure (SBP) after NSPT.
Moderate certainty evidence shows that NSPT has a positive effect on the reduction of IL-6 and SBP in patients with periodontitis, while low certainty evidence shows that NSPT is effective for reduction of CRP. Moderate certainty evidence showed that NSPT did not show a positive effect on low-density lipoprotein (LDL), high-density lipoprotein (HDL), total cholesterol (TC) and triglycerides (TG), and low certainty evidence showed that NSPT did not show a positive effect on Interleukin-1β (IL-1β), tumor necrosis factor-alpha (TNF-α), diastolic blood pressure (DBP), and flow-mediated dilatation (FMD).
The protocol was registered in the PROSPERO (International Prospective Register of Systematic Reviews), number CRD42022377565.
心血管疾病（CVD）是全球主要的死亡原因。患有牙周炎的患者患 CVD 的风险更高，尽管这些疾病之间的因果关系尚不清楚。非手术牙周治疗（NSPT）能够控制局部和全身的炎症。本研究旨在分析 NSPT 对 CVD 风险标志物的影响。
从各数据库成立之初至 2023 年 4 月 1 日，对无任何语言限制的文章进行检索和筛选，共纳入 21 项随机对照临床试验。选择 11 个与 CVD 相关的标志物（如 C 反应蛋白[CRP]、白细胞介素-6[IL-6]）进行荟萃分析。使用随机和固定效应模型进行荟萃分析。差异表示为加权均数差（WMD）和 95%置信区间（95%CI）。
从 1353 项研究中，有 21 项随机对照临床试验纳入荟萃分析。结果表明，NSPT 后 CRP、IL-6 和收缩压（SBP）显著降低。
中等确定性证据表明，NSPT 对牙周炎患者的 IL-6 和 SBP 降低有积极作用，而低确定性证据表明，NSPT 对 CRP 降低有效。中等确定性证据表明，NSPT 对低密度脂蛋白（LDL）、高密度脂蛋白（HDL）、总胆固醇（TC）和甘油三酯（TG）没有积极影响，低确定性证据表明，NSPT 对白细胞介素-1β（IL-1β）、肿瘤坏死因子-α（TNF-α）、舒张压（DBP）和血流介导的扩张（FMD）没有积极影响。
该方案在 PROSPERO（国际前瞻性系统评价注册库）中注册，编号为 CRD42022377565。
