Department of Life, Health & Environmental Sciences, University of L'Aquila, Italy; Center of Oral Diseases, Prevention and Translational Research - Dental Clinic, L'Aquila, Italy; Oral Diseases and Systemic Interactions Study Group (ODISSY Group), L'Aquila, Italy; PhD School in Medicine and Public Health.
Department of Life, Health & Environmental Sciences, University of L'Aquila, Italy; Oral Diseases and Systemic Interactions Study Group (ODISSY Group), L'Aquila, Italy; Unit of Internal Medicine and Nephrology, Center for Hypertension and Cardiovascular Prevention, San Salvatore Hospital, L'Aquila, Italy.
Trends Cardiovasc Med. 2024 May;34(4):267-275. doi: 10.1016/j.tcm.2023.03.003. Epub 2023 Mar 23.
Cardiovascular diseases (CVDs) are a leading cause of morbidity and mortality worldwide with a high socioeconomic burden. Increasing evidence supports a convincing connection with increased cardiovascular risk of periodontal diseases (PD), a group of widespread, debilitating, and costly dysbiotic relapsing-remitting inflammatory diseases of the tissues supporting the teeth. Herein, we ensembled the best available evidence on the connection between CVDs and PD to review the recently emerging concept of the latter as a non-traditional risk factor for CVDs. We focused on oral dysbiosis, inflammation-associated molecular and cellular mechanisms, and epigenetic changes as potential causative links between PD and CVDs. The available evidence on the effects of periodontal treatment on cardiovascular risk factors and diseases was also described.
心血管疾病（CVDs）是全球发病率和死亡率的主要原因，具有较高的社会经济负担。越来越多的证据支持牙周病（PD）与心血管风险增加之间存在令人信服的联系，牙周病是一组广泛存在的、使人虚弱的、代价高昂的、以牙齿支持组织为病变部位的、复发性、缓解性、生态失调性炎症性疾病。在此，我们汇集了 CVDs 和 PD 之间关联的最佳现有证据，以综述后者作为 CVDs 非传统危险因素的新出现概念。我们重点关注口腔生态失调、炎症相关的分子和细胞机制以及表观遗传变化作为 PD 和 CVDs 之间的潜在因果联系。还描述了牙周治疗对心血管危险因素和疾病影响的现有证据。
