[Study on hypoxemia during sleep in patients with chronic obstructive pulmonary disease].

OBJECTIVE

To investigate the influence of hypoxemia during sleep on elements of polysomnography (PSG) in patients with chronic obstructive pulmonary disease (COPD) and the correlation of sleep hypoxemia and arterial blood gases, pulmonary function in daytime.

METHODS

Two hundred and four moderate to very severe stable COPD patients with an age range of 40-75 years [mean age was (70.41+/-7.84) years ] were admitted. All patients underwent overnight PSG, and percentage of the time with oxygen saturation below 0.90 and total sleep time (T90)>or=5% was taken as nocturnal oxygen desaturation (NOD), and if not, they were non-NOD. Arterial blood gases, lung function and PSG examinations were performed in all patients.

RESULTS

Ninety-five patients (46.57%) had NOD were enrolled. Compared with patients of non-NOD, both daytime oxygen saturation (SaO2, 0.90+/-0.04 vs. 0.94+/-0.01) and nocturnal mean SaO2 (MSaO2, 0.83+/-0.08 vs. 0.93+/-0.02) in NOD were lower significantly (both P<0.01). Sleep-related elements such as awake period (minutes: 97.86+/-41.74 vs. 76.13+/-55.15), awake frequency (times: 31.50+/-15.69 vs. 23.23+/-19.81), mean heart rate (beat per min: 80.80+/-12.80 vs. 66.21+/-6.53), sleep components [(S1+S2)%: (74.36+/-16.52)% vs. (67.55+/-12.62)%, (S3+S4)%: (12.99+/-12.18)% vs. (19.35+/-12.71)%] in NOD were significantly different from non-NOD (all P<0.01). The levels of arterial partial pressure of carbon dioxide (PaCO2), arterial partial pressure of oxygen (PaO2), percentage of forced expiratory volume in one second (FEV1) and anticipate value, percentage of forced vital capacity (FVC) and anticipate value, percentage of FEV1/FVC and anticipate value in daytime were respectively correlated with the T90, MSaO2 and minimum SaO2 (miniSaO2) in sleep. Among these measurements, PaCO2 was best correlated with sleep hypoxemia (r1=0.767, r2=-0.758, r3=-0.689, all P<0.01).

CONCLUSION

Sleep hypoxemia existed generally in patients with moderate to very severe stable COPD. There was significant difference in nocturnal SaO2, daytime SaO2 and sleep-related elements between NOD and non-NOD. The measurements in daytime are correlated with sleep hypoxemia, and some of them may predict sleep hypoxemia.