Etemadzadeh H
Department of Periodontology, University of Helsinki, Finland.
J Clin Periodontol. 1991 May;18(5):337-40. doi: 10.1111/j.1600-051x.1991.tb00438.x.
The plaque-reducing effect of a chewing gum containing hydrogen peroxide was assessed. 12 dental hygienist students participated in a double-blind 3 x randomly crossed-over study. During the 4-day test periods, from Monday to Friday, no oral hygiene measures were allowed other than chewing 2 pieces of gum for approximately 10 min 5 x daily. The 800 mg pieces of gum were V6+regular (V6+) containing 0.4 g sorbitol and 6.3 mg hydrogen peroxide, V6 placebo gum (PLAC) containing 0.45 g sorbitol and no hydrogen peroxide, and only the gum base (GB) as a negative control. The quantity of plaque was assessed using the plaque index and the visible plaque index, and by scraping "all" plaque off the teeth in half the mouth during 2.5 min for determination of plaque wet weight. With all 3 measurements, chewing of the hydrogen peroxide-releasing gum (V6+) resulted in significantly lower plaque increments, from Monday to Friday, than chewing of the gum base (P less than 0.05). Chewing of the V6 placebo gum (PLAC) resulted in plaque scores which differed from neither those recorded after use of the hydrogen peroxide releasing (V6+) nor the placebo (GB) gums. The observed plaque-growth inhibiting effect of the hydrogen peroxide-releasing chewing gum in the present study was found to be of limited clinical significance.
评估了一种含过氧化氢口香糖的减少牙菌斑效果。12名牙科保健专业学生参与了一项双盲3×随机交叉研究。在为期4天的测试期内，即从周一至周五，除每天5次咀嚼2片口香糖约10分钟外，不允许采取其他口腔卫生措施。800毫克的口香糖有含0.4克山梨醇和6.3毫克过氧化氢的V6 +常规型（V6 +）、含0.45克山梨醇且不含过氧化氢的V6安慰剂口香糖（PLAC）以及仅作为阴性对照的胶基（GB）。使用菌斑指数和可见菌斑指数评估菌斑量，并在2.5分钟内刮下半边口腔牙齿上的“所有”菌斑以测定菌斑湿重。通过这三种测量方法，从周一至周五，咀嚼释放过氧化氢的口香糖（V6 +）导致的菌斑增量显著低于咀嚼胶基（P小于0.05）。咀嚼V6安慰剂口香糖（PLAC）产生的菌斑评分与咀嚼释放过氧化氢的（V6 +）或安慰剂（GB）口香糖后记录的评分均无差异。在本研究中观察到的释放过氧化氢口香糖对菌斑生长的抑制作用在临床上意义有限。
