Banakar Morteza, Moayedi Sedigheh, Shamsoddin Erfan, Vahedi Zahra, Banakar Mohammad Hasan, Mousavi Seyyed Mojtaba, Rokaya Dinesh, Bagheri Lankarani Kamran
Dental Research Center, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Health Policy Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran.
Int J Dent. 2022 Jun 20;2022:9430988. doi: 10.1155/2022/9430988. eCollection 2022.
Drug delivery approaches with the shortest therapeutic period and the lowest side effects have always been considered a sublime target in the medical sciences. Among many delivery methods, chewing gum could be perceived as a promising drug carrier that can carry several types of drugs for oral health. These drug carriers could represent optimal therapeutic time and lower side effects due to their sustained release capability and lower required thresholds for the drug compared with other delivery approaches. The convenient use in the oral cavity's local environment and the ability to locally carry multiple drugs are considered the main advantages of this delivery approach.
This review aimed to explore chewing gum as a promising drug carrier that can carry several types of drugs for oral health.
Articles were searched for on PubMed, ISI, SCOPUS, Google Patents, the Royal Society of Chemistry website, and electronic databases using MESH terms and the following keywords: ("Gum" OR "Chewing gum") and ("Drug delivery OR Drug delivery systems") in the English language. No time limit was applied, and all documents as of August 30th, 2020 were retrieved.
Gum-drug interactions, mechanisms of release, and formulations of the drugs might all play a role in this versatile delivery method. Accordingly, chewing gum-based carriers may be presented as a plausible candidate for drug delivery in oral diseases.
Gum-driven drugs could be introduced as promising candidates for treating oral diseases due to their ability to deliver the proper local dosages of active ingredients, short contact time, biocompatibility, and biodegradable chemical structures.
治疗周期最短且副作用最小的药物递送方法一直被视为医学领域的崇高目标。在众多递送方法中，口香糖可被视为一种有前景的药物载体，能够携带多种用于口腔健康的药物。与其他递送方法相比，这些药物载体由于其缓释能力以及对药物较低的需求阈值，可实现最佳治疗时间并降低副作用。在口腔局部环境中使用方便以及能够局部携带多种药物被认为是这种递送方法的主要优点。
本综述旨在探讨口香糖作为一种有前景的药物载体，能够携带多种用于口腔健康的药物。
在PubMed、ISI、SCOPUS、谷歌专利、英国皇家化学学会网站以及电子数据库中使用医学主题词（MESH）和以下英文关键词进行文献检索：（“口香糖”或“咀嚼胶”）以及（“药物递送”或“药物递送系统”）。不设时间限制，检索截至2020年8月30日的所有文献。
口香糖与药物的相互作用、释放机制以及药物配方可能在这种多功能递送方法中都发挥作用。因此，基于口香糖的载体可能是口腔疾病药物递送的一个合理候选者。
基于口香糖的药物由于能够递送适当的局部活性成分剂量、接触时间短、生物相容性好以及具有可生物降解的化学结构，可被视为治疗口腔疾病的有前景的候选药物。
