Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA.
Semin Liver Dis. 2010 Aug;30(3):232-44. doi: 10.1055/s-0030-1255353. Epub 2010 Jul 21.
Inflammation is strongly associated with chronic hepatic injury and the ensuing wound-healing process. Recent evidence from mouse models and human studies implicates Toll-like receptors (TLRs) as important regulators of the inflammatory response and a functional link between inflammation and fibrosis in the chronically injured liver. Here, we review mechanisms by which TLR4 and TLR4 ligands from the intestinal microbiota contribute to hepatic injury, inflammation, hepatic stellate cell activation, and fibrosis.
炎症与慢性肝损伤及随后的伤口愈合过程密切相关。来自小鼠模型和人类研究的最新证据表明，Toll 样受体（TLRs）是炎症反应的重要调节因子，炎症和慢性损伤肝脏中的纤维化之间存在功能联系。在这里，我们综述了 TLR4 及其肠道微生物群配体促进肝损伤、炎症、肝星状细胞激活和纤维化的机制。
