toll 样受体 4 与肝纤维化。
Toll-like receptor 4 and hepatic fibrogenesis.
机构信息
Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA.
出版信息
Semin Liver Dis. 2010 Aug;30(3):232-44. doi: 10.1055/s-0030-1255353. Epub 2010 Jul 21.
Abstract
Inflammation is strongly associated with chronic hepatic injury and the ensuing wound-healing process. Recent evidence from mouse models and human studies implicates Toll-like receptors (TLRs) as important regulators of the inflammatory response and a functional link between inflammation and fibrosis in the chronically injured liver. Here, we review mechanisms by which TLR4 and TLR4 ligands from the intestinal microbiota contribute to hepatic injury, inflammation, hepatic stellate cell activation, and fibrosis.
摘要
炎症与慢性肝损伤及随后的伤口愈合过程密切相关。来自小鼠模型和人类研究的最新证据表明，Toll 样受体（TLRs）是炎症反应的重要调节因子，炎症和慢性损伤肝脏中的纤维化之间存在功能联系。在这里，我们综述了 TLR4 及其肠道微生物群配体促进肝损伤、炎症、肝星状细胞激活和纤维化的机制。
相似文献
1
Toll-like receptor 4 and hepatic fibrogenesis.
Semin Liver Dis. 2010 Aug;30(3):232-44. doi: 10.1055/s-0030-1255353. Epub 2010 Jul 21.
2
Inflammation and hepatic fibrosis.
Semin Liver Dis. 2010 Aug;30(3):211-4. doi: 10.1055/s-0030-1255350. Epub 2010 Jul 21.
3
Macrophages: master regulators of inflammation and fibrosis.
Semin Liver Dis. 2010 Aug;30(3):245-57. doi: 10.1055/s-0030-1255354. Epub 2010 Jul 21.
4
Chemokines in liver inflammation and fibrosis.
Semin Liver Dis. 2010 Aug;30(3):215-25. doi: 10.1055/s-0030-1255351. Epub 2010 Jul 21.
5
Metabolic inflammation as an instigator of fibrosis during non-alcoholic fatty liver disease.
World J Gastroenterol. 2020 May 7;26(17):1993-2011. doi: 10.3748/wjg.v26.i17.1993.
6
Toll-like receptor-4 expression by hepatic progenitor cells and biliary epithelial cells in HCV-related chronic liver disease.
Mod Pathol. 2012 Apr;25(4):576-89. doi: 10.1038/modpathol.2011.197. Epub 2011 Dec 16.
7
Liver fibrosis: mechanisms of immune-mediated liver injury.
Cell Mol Immunol. 2012 Jul;9(4):296-301. doi: 10.1038/cmi.2011.53. Epub 2011 Dec 12.
8
Hepatic stellate cells specific liposomes with the Toll-like receptor 4 shRNA attenuates liver fibrosis.
J Cell Mol Med. 2021 Jan;25(2):1299-1313. doi: 10.1111/jcmm.16209. Epub 2020 Dec 18.
9
ADAR1 deletion induces NFκB and interferon signaling dependent liver inflammation and fibrosis.
RNA Biol. 2017 May 4;14(5):587-602. doi: 10.1080/15476286.2016.1203501. Epub 2016 Jun 30.
10
HIV-1 gp120 signaling through TLR4 modulates innate immune activation in human macrophages and the biology of hepatic stellate cells.
J Leukoc Biol. 2016 Sep;100(3):599-606. doi: 10.1189/jlb.4A1215-534R. Epub 2016 Mar 18.
引用本文的文献
1
Bacterial extracellular vesicles: emerging mediators of gut-liver axis crosstalk in hepatic diseases.
Front Cell Infect Microbiol. 2025 Jun 20;15:1620829. doi: 10.3389/fcimb.2025.1620829. eCollection 2025.
2
New insights in the pathogenesis of alcohol-related liver disease: The metabolic, immunologic, and neurologic pathways.
Liver Res. 2022 Oct 3;7(1):1-8. doi: 10.1016/j.livres.2022.09.004. eCollection 2023 Mar.
3
An original donor-dependent spheroid system for the prediction of idiosyncratic drug-induced liver injury risk.
In Vitro Model. 2023 Aug 15;2(6):281-295. doi: 10.1007/s44164-023-00057-w. eCollection 2023 Dec.
4
A review of MASLD-related hepatocellular carcinoma: progress in pathogenesis, early detection, and therapeutic interventions.
Front Med (Lausanne). 2024 Jun 4;11:1410668. doi: 10.3389/fmed.2024.1410668. eCollection 2024.
5
Impact of small intestinal bacterial overgrowth on systemic inflammation, circulatory and renal function, and liver fibrosis in patients with cirrhosis and ascites.
Ann Gastroenterol. 2024 May-Jun;37(3):348-355. doi: 10.20524/aog.2024.0881. Epub 2024 Apr 26.
6
TGFβR1 inhibition drives hepatocellular carcinoma proliferation through induction of toll-like-receptor signalling.
Int J Exp Pathol. 2024 Apr;105(2):64-74. doi: 10.1111/iep.12501. Epub 2024 Feb 8.
7
Immune and metabolic cross-links in the pathogenesis of comorbid non-alcoholic fatty liver disease.
World J Gastroenterol. 2023 Jan 28;29(4):597-615. doi: 10.3748/wjg.v29.i4.597.
8
Administration in 5/6 Nephrectomized Mice Enhanced Fibrosis in Internal Organs: An Impact of Lipopolysaccharide and (1→3)-β-D-Glucan from Leaky Gut.
Int J Mol Sci. 2022 Dec 15;23(24):15987. doi: 10.3390/ijms232415987.
9
Mechanisms and application strategies of miRNA‑146a regulating inflammation and fibrosis at molecular and cellular levels (Review).
Int J Mol Med. 2023 Jan;51(1). doi: 10.3892/ijmm.2022.5210. Epub 2022 Dec 9.
10
Polyguanine alleviated autoimmune hepatitis through regulation of macrophage receptor with collagenous structure and TLR4-TRIF-NF-κB signalling.
J Cell Mol Med. 2022 Nov;26(22):5690-5701. doi: 10.1111/jcmm.17599. Epub 2022 Oct 25.
本文引用的文献
1
In liver fibrosis, dendritic cells govern hepatic inflammation in mice via TNF-alpha.
J Clin Invest. 2009 Nov;119(11):3213-25. doi: 10.1172/JCI37581. Epub 2009 Oct 12.
2
Toll-like receptor 4 is involved in the development of fructose-induced hepatic steatosis in mice.
Hepatology. 2009 Oct;50(4):1094-104. doi: 10.1002/hep.23122.
3
CCR1 and CCR5 promote hepatic fibrosis in mice.
J Clin Invest. 2009 Jul;119(7):1858-70. doi: 10.1172/jci37444.
4
Multiple variants in toll-like receptor 4 gene modulate risk of liver fibrosis in Caucasians with chronic hepatitis C infection.
J Hepatol. 2009 Oct;51(4):750-7. doi: 10.1016/j.jhep.2009.04.027. Epub 2009 Jun 18.
5
The interleukin-1 receptor/Toll-like receptor superfamily: 10 years of progress.
Immunol Rev. 2008 Dec;226:10-8. doi: 10.1111/j.1600-065X.2008.00701.x.
6
VSL#3 probiotic treatment attenuates fibrosis without changes in steatohepatitis in a diet-induced nonalcoholic steatohepatitis model in mice.
Hepatology. 2009 Mar;49(3):989-97. doi: 10.1002/hep.22711.
7
Functional linkage of cirrhosis-predictive single nucleotide polymorphisms of Toll-like receptor 4 to hepatic stellate cell responses.
Hepatology. 2009 Mar;49(3):960-8. doi: 10.1002/hep.22697.
8
Toll-like receptor and RIG-I-like receptor signaling.
Ann N Y Acad Sci. 2008 Nov;1143:1-20. doi: 10.1196/annals.1443.020.
9
High-mobility group box 1 protein activates hepatic stellate cells in vitro.
Transplant Proc. 2008 Oct;40(8):2704-5. doi: 10.1016/j.transproceed.2008.07.055.
10
The critical role of toll-like receptor (TLR) 4 in alcoholic liver disease is independent of the common TLR adapter MyD88.
Hepatology. 2008 Oct;48(4):1224-31. doi: 10.1002/hep.22470.
Zotero 插件