Orii S, Sugai T, Nakano O, Yoshinari H, Sato S
First Department of Internal Medicine, School of Medicine, Iwate Medical University, Morioka, Japan.
J Clin Gastroenterol. 1991 Jun;13(3):325-7.
A 19-year-old man with a documented 2-year history of Crohn's disease abruptly developed leukopenia and thrombocytopenia. A diagnosis of acute promyelocytic leukemia was established by bone marrow cytology. Chromosomal analysis of bone marrow aspirate revealed aberrations of no. 8 trisomy and translocation between no. 15 and no. 17 [46,XY,t(15q+,17q-)/47,XY,+8,t(15q+,17q-)]. Nine cases of Crohn's disease complicated by leukemia have been reported, including the present one; once again, a relationship between Crohn's disease and leukemia is suggested.
