Centre for Voice and Swallowing, University of California, Davis, Sacramento, California, USA.
Laryngoscope. 2010 Aug;120(8):1498-503. doi: 10.1002/lary.21002.
OBJECTIVES/HYPOTHESIS: Cricopharyngeus muscle dysfunction (CPD) ranges from asymptomatic cricopharyngeal bar (CPB) to Zenker's diverticulum. Previous work suggests that CPD can result in dilation and weakening of the pharynx above the obstruction. The purpose of this investigation was to evaluate the ability of surgery on the cricopharyngeus muscle to improve pharyngeal area and strength.
Retrospective case study.
Videofluoroscopic swallowing studies of all persons with CPD who underwent cricopharyngeus (CP) intervention followed by routine postoperative fluoroscopic study, between October 1, 1999 and January 1, 2010 were reviewed. Objective measures of pharyngeal area and constriction were obtained from pretreatment and post-treatment studies. Paired t tests and repeated measures analysis of variance were employed to compare results.
Fifty-four patients were included. Pharyngeal constriction and pharyngoesophageal segment (PES) opening improved significantly after intervention (P < .05).Pharyngeal dilation was unchanged (P > .05). PES opening improved more with CP myotomy than with dilation and botulinum toxin.
Relief of CP obstruction by surgery or dilation improves pharyngeal constriction and PES opening. Dilation of the pharynx possibly related to prolonged outlet obstruction does not improve. CP myotomy appears more effective than dilation or botulinum toxin in relieving obstruction.
目的/假设:环咽肌功能障碍(CPD)的范围从无症状的环咽肌缩窄(CPB)到Zenker 憩室。先前的工作表明,CPD 可导致梗阻上方咽的扩张和减弱。本研究的目的是评估环咽肌手术改善咽区和强度的能力。
回顾性病例研究。
对 1999 年 10 月 1 日至 2010 年 1 月 1 日期间所有接受环咽肌(CP)干预的 CPD 患者进行回顾性分析,随后进行常规术后荧光透视研究。从术前和术后研究中获得咽区和收缩的客观测量值。采用配对 t 检验和重复测量方差分析比较结果。
共纳入 54 例患者。干预后咽缩窄和咽食管段(PES)开口明显改善(P<.05)。咽扩张无变化(P>.05)。CP 肌切开术比扩张和肉毒毒素治疗改善 PES 开口更有效。
手术或扩张缓解 CP 梗阻可改善咽缩窄和 PES 开口。与延长出口梗阻相关的咽扩张可能不会改善。CP 肌切开术在缓解梗阻方面似乎比扩张或肉毒毒素更有效。