Department of Biostructure and Animal Physiology, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, Norwida 31, Wroclaw, Poland.
J Anim Physiol Anim Nutr (Berl). 2011 Feb;95(1):114-24. doi: 10.1111/j.1439-0396.2010.01033.x.
We studied the effects of Scutellaria baicalensis root on blood parameters and antioxidant enzyme activities in rabbits fed a high-cholesterol diet. Thirty-two New Zealand White rabbits were divided into four groups of eight animals each. They were fed a standard diet (C group), a diet with a 1% pure cholesterol supplement (CH group), a diet with a 1% pure cholesterol supplement and a 9% skullcap root supplement (CH+SR group), or a diet with a 9% skullcap root supplement (SR group). After 6 weeks, the rabbits fed the high-cholesterol diet had significantly decreased RBC and Hb levels and significantly increased MCV, MCH and Fe levels (p≤ 0.05). The skullcap root supplement had no adverse effects on the haematological parameters. The values for RBC, Hb, HCT, MCV, MCH and MCHC were similar in the skullcap root-treated and control rabbits. We also observed a remarkable elevation in the serum TC, LDL and TG levels at the end of the 6-week period. The rabbits fed the cholesterol diet showed decreased activity of the erythrocyte GSH-Px compared with the rabbits fed the basal diet. The GSH-Px activity was significantly higher in the rabbits fed the CH+SR diet than in those on the CH diet. The erythrocyte SOD activity was also significantly decreased in the rabbits on the CH diet. However, the CH+SR group rabbits showed significantly enhanced erythrocyte SOD activity. The SOD level in the CH+SR rabbits was 34.91 U/ml, which was a 23% increase (p≤ 0.05) in relation to the results for the CH group and only 15% diminished in relation to the control group. These results suggest that the dietary supplementation of skullcap root may improve rabbit antioxidant systems and protect against the risks from a high-cholesterol diet.
我们研究了黄芩根对喂饲高胆固醇饮食的兔血液参数和抗氧化酶活性的影响。将 32 只新西兰白兔分为 4 组，每组 8 只。一组喂饲标准饮食（C 组），一组喂饲含 1%纯胆固醇补充剂的饮食（CH 组），一组喂饲含 1%纯胆固醇补充剂和 9%黄芩根补充剂的饮食（CH+SR 组），一组喂饲含 9%黄芩根补充剂的饮食（SR 组）。6 周后，喂饲高胆固醇饮食的兔的 RBC 和 Hb 水平显著降低，MCV、MCH 和 Fe 水平显著升高（p≤0.05）。黄芩根补充剂对血液学参数无不良影响。黄芩根处理组和对照组兔的 RBC、Hb、HCT、MCV、MCH 和 MCHC 值相似。我们还观察到 6 周结束时血清 TC、LDL 和 TG 水平显著升高。喂饲胆固醇饮食的兔的红细胞 GSH-Px 活性与喂饲基础饮食的兔相比显著降低。与 CH 饮食组相比，CH+SR 饮食组的 GSH-Px 活性显著升高。CH 饮食组的红细胞 SOD 活性也显著降低。然而，CH+SR 组兔的红细胞 SOD 活性显著增强。CH+SR 兔的 SOD 水平为 34.91 U/ml，与 CH 组相比增加了 23%（p≤0.05），与对照组相比降低了 15%。这些结果表明，黄芩根的膳食补充可能改善兔的抗氧化系统，预防高胆固醇饮食的风险。
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