一项对 1557 例扁平苔藓患者乙型肝炎和丙型肝炎相关性的研究。

A study on the association with hepatitis B and hepatitis C in 1557 patients with lichen planus.

机构信息

Clalit Health Services Siaal Research Center for Family Medicine and Primary Care Department of Epidemiology and Health Services Evaluation, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

出版信息

J Eur Acad Dermatol Venereol. 2011 Apr;25(4):436-40. doi: 10.1111/j.1468-3083.2010.03809.x.

DOI:10.1111/j.1468-3083.2010.03809.x

PMID:20666875

Abstract

BACKGROUND

Previous reports have demonstrated contradicting results on the association between lichen planus and hepatitis.

OBJECTIVES

The aim of this study was to investigate the association between lichen planus and viral hepatitis.

METHODS

Patients with lichen planus were compared with controls regarding the prevalence of viral hepatitis in a case-control study using logistic multivariate regression models. The study was performed utilizing the medical database of Clalit Health Services.

RESULTS

The study included 1557 lichen planus patients over the age of 20 years and 3115 age- and gender-matched controls. The prevalence of hepatitis C in patients with lichen planus was higher than that in the control group (1.9%, 0.4% respectively, P<0.001). In a multivariate analysis, lichen planus was associated with hepatitis C (OR 4.19, 95% CI 2.21; 7.93). The prevalence of hepatitis B in patients with lichen planus was similar to that in the control group (0.9%, 0.5% respectively, P=0.12). A multivariate analysis revealed that lichen planus was not associated with hepatitis B (OR 1.69, 95% CI 0.82; 3.47).

CONCLUSION

Lichen planus is associated with hepatitis C but not with hepatitis B. Physicians who care for patients with lichen planus should consider screening patients with lichen planus for hepatitis C.

摘要

背景

先前的报告表明，扁平苔藓与肝炎之间的关联结果相互矛盾。

目的

本研究旨在调查扁平苔藓与病毒性肝炎之间的关联。

方法

采用病例对照研究，使用逻辑多元回归模型，将患有扁平苔藓的患者与对照组进行比较，以评估病毒性肝炎的患病率。该研究利用了 Clalit 健康服务的医疗数据库。

结果

本研究纳入了 1557 名年龄在 20 岁以上的扁平苔藓患者和 3115 名年龄和性别匹配的对照组。患有扁平苔藓的患者中丙型肝炎的患病率高于对照组（分别为 1.9%和 0.4%，P<0.001）。在多变量分析中，扁平苔藓与丙型肝炎相关（OR 4.19，95%CI 2.21；7.93）。患有扁平苔藓的患者乙型肝炎的患病率与对照组相似（分别为 0.9%和 0.5%，P=0.12）。多变量分析显示，扁平苔藓与乙型肝炎无关（OR 1.69，95%CI 0.82；3.47）。