Department of Neurology, Huadong Hospital, Fudan University, Shanghai, China.
Neuropathology. 2011 Apr;31(2):112-21. doi: 10.1111/j.1440-1789.2010.01137.x.
Vascular factors have been shown to be important in cognitive impairment and dementia in the elderly. Recent evidence suggests that treatment at the stage of mild cognitive impairment (MCI) can prevent progression to dementia. In this study we established a rat model that simulates the pathophysiological condition of vascular MCI, characterized by gait disturbance in the absence of motor deficits and mild working memory dysfunction and not being demented. Initiation of vascular MCI pathology was not associated with loss of neurons, but was correlated with microglial activation and white matter changes. This MCI rat model will be useful for analysis of effects of vascular factors on cognitive dysfunction and neurodegenerative processes and development of drugs for treatment of this disorder.
血管因素已被证明在老年人的认知障碍和痴呆中起重要作用。最近的证据表明，在轻度认知障碍（MCI）阶段进行治疗可以预防痴呆的进展。在这项研究中，我们建立了一个模拟血管性 MCI 病理生理状况的大鼠模型，其特征为运动缺陷缺失、轻度工作记忆功能障碍但无痴呆的步态障碍。血管性 MCI 病理的发生与神经元丢失无关，但与小胶质细胞激活和白质变化相关。这种 MCI 大鼠模型将有助于分析血管因素对认知功能障碍和神经退行性过程的影响，并开发治疗这种疾病的药物。
