Sakai H, Sakai N, Nakahara I, Shimozuru T, Higashi T, Takahashi J C, Ohta H, Kokuzawa J, Manaka H, Morizane A, Kawabata Y, Nagata I, Kikuchi H
Department of Neurosurgery, National Cardio-Vascular Center; Osaka, Japan -
Interv Neuroradiol. 2000 Nov 30;6 Suppl 1(Suppl 1):223-6. doi: 10.1177/15910199000060S137. Epub 2001 May 15.
The purpose of this study was to evaluate asymptomatic embolisms during cerebral endovascular surgery for cerebrovascular diseases with diffusion-weighted magnetic resonance imaging (DWI) which allowed sensitive and early detection of cerebral ischemic lesions. 71 patients who underwent a total of 74 cerebral endovascular procedures were subjected to DWI screening study. MR imaging was performed on a 1.5T system by using single-shot SE echo-planar imaging (EPI) with b value of 1100 seconds per mm(2) in pre- and post-treatment periods (between day 2 and 5 after procedures). In 38 (51.3%) of 74 procedures, new high intensity lesions, as recent infarctions related to procedures, were detected on post-procedural DWI. In 18 Of the patients (47.4%), symptomatic infarctions occurred and resulted in TIAs (n = 4), RINDs (n = 8), minor strokes (n = 6) and no major strokes and no death. 20 (52.6%) of the recent infarctions detected by DWI were asymptomatic lesions.Most of the asymptomatic ischemic lesions were likely to be distributed in watershed border areas. On the other hand, symptomatic lesions tended to be distributed in cortical and/or perforator regions and to be multiple. Thus, DWI is a useful method that can detect neurologically silent and asymptomatic ischemic lesions. It can be used to help to evaluate the safety and efficacy of neurovascular intervention.
本研究的目的是利用扩散加权磁共振成像(DWI)评估脑血管疾病的脑内血管手术期间的无症状栓塞情况,该成像技术能够敏感且早期检测脑缺血性病变。71例患者共接受了74次脑内血管手术,并进行了DWI筛查研究。在治疗前和治疗后阶段(手术后天2至5之间),使用单次激发SE回波平面成像(EPI),b值为1100秒每平方毫米,在1.5T系统上进行磁共振成像。在74次手术中的38次(51.3%)中,术后DWI检测到新的高强度病变,为与手术相关的近期梗死。18例患者(47.4%)发生了有症状的梗死,导致短暂性脑缺血发作(n = 4)、可逆性缺血性神经功能障碍(RIND,n = 8)、轻度卒中(n = 6),无重度卒中且无死亡。DWI检测到的近期梗死中有20次(52.6%)为无症状病变。大多数无症状缺血性病变可能分布在分水岭边界区域。另一方面,有症状病变倾向于分布在皮质和/或穿支区域,且为多发性。因此,DWI是一种有用的方法,可检测神经学上无症状的缺血性病变。它可用于帮助评估神经血管介入的安全性和有效性。