尿液中美沙酮和2-乙基-1,5-二甲基-3,3-二苯基吡咯烷（EDDP）的同步气相色谱/质谱测定法。
Simultaneous gas chromatography/mass spectrometry assay of methadone and 2-ethyl-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP) in urine.
作者信息
Baugh L D, Liu R H, Walia A S
机构信息
Department of Criminal Justice, University of Alabama, Birmingham.
出版信息
J Forensic Sci. 1991 Mar;36(2):548-55.
An efficient extraction and gas chromatography/mass spectrometry (GC/MS) procedure has been developed for the simultaneous determination of methadone and 2-ethyl-1,5-dimethyl-3,3-diphenylpyrrolidine in urine samples. The merits of this procedure include (1) effective high-volume sample processing; (2) excellent gas chromatography characteristics; (3) high precision for quantitative methadone determination--1.0% coefficient of variation (CV) for GC/MS injection replicates and 1.2% for extraction replicates; (4) excellent linearity within the range (0 to 1200 ng/mL) studied; and (5) adequate detection limits (50 ng/mL) for most practical purposes. The detection limit for methadone may be improved 40-fold by using a different internal standard.
已开发出一种高效的提取和气相色谱/质谱（GC/MS）方法，用于同时测定尿液样本中的美沙酮和2-乙基-1,5-二甲基-3,3-二苯基吡咯烷。该方法的优点包括：（1）有效的大容量样本处理；（2）出色的气相色谱特性；（3）美沙酮定量测定的高精度——GC/MS进样重复分析的变异系数（CV）为1.0%，提取重复分析的变异系数为1.2%；（4）在所研究的范围（0至1200 ng/mL）内具有出色的线性；（5）对于大多数实际应用而言，检测限足够（5 ng/mL）。通过使用不同的内标，美沙酮的检测限可提高40倍。
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