Ohtake T, Kosaka N, Watanabe T, Yokoyama I, Moritan T, Masuo M, Iizuka M, Kozeni K, Momose T, Oku S
Department of Radiology, University of Tokyo, Japan.
J Nucl Med. 1991 Jul;32(7):1432-8.
We have developed a method for the noninvasive estimation of regional tissue glucose utilization in humans that employs positron emission tomography (PET) and 2-(18F)fluoro-2-deoxy-d-glucose (FDG). Unlike other methods, the input function used in this method is obtained from the corrected time-activity curve of the descending aorta, not the left ventricle, because the descending aorta is relatively free of spillover from other organs and extends from the upper thorax to the lower abdomen. With this method the time-activity curve of the descending aorta must be corrected for the partial volume effect and the difference in counts between plasma and whole blood. Using the noninvasively obtained input function, regional tissue glucose utilization was calculated by Patlak graphic analysis. k1k3/(k2 + k3) was in good agreement with k1k3/(k2 + k3) calculated from the plasma input function by arterial sampling (r = 0.9995). These results suggest that the input function and regional tissue glucose utilization (not only of myocardium but also of other thoracic and abdominal organs) can be determined noninvasively.
我们已经开发出一种用于无创估计人体局部组织葡萄糖利用率的方法，该方法采用正电子发射断层扫描（PET）和2-（18F）氟-2-脱氧-D-葡萄糖（FDG）。与其他方法不同，此方法中使用的输入函数是从降主动脉的校正时间-活性曲线获得的，而非左心室，因为降主动脉相对较少受到其他器官的溢出影响，且从胸部上方延伸至腹部下方。使用此方法时，降主动脉的时间-活性曲线必须针对部分容积效应以及血浆与全血之间的计数差异进行校正。利用无创获得的输入函数，通过Patlak图形分析计算局部组织葡萄糖利用率。k1k3/（k2 + k3）与通过动脉采样从血浆输入函数计算得出的k1k3/（k2 + k3）高度吻合（r = 0.9995）。这些结果表明，可以无创地确定输入函数和局部组织葡萄糖利用率（不仅是心肌，还有其他胸部和腹部器官的）。
