Turku PET Centre, University of Turku, Turku, Finland.
Department of Endocrinology, Turku University Hospital, Turku, Finland.
Eur J Endocrinol. 2022 Nov 30;187(6):917-928. doi: 10.1530/EJE-22-0509. Print 2022 Dec 1.
To investigate whether alterations in brain glucose uptake (BGU), insulin action in the brain-liver axis and whole-body insulin sensitivity occur in young adults in pre-obese state.
Healthy males with either high risk (HR; n = 19) or low risk (LR; n = 22) for developing obesity were studied with [18F]fluoro-d-glucose ([18F]FDG)-positron emission tomography during hyperinsulinemic-euglycemic clamp. Obesity risk was assessed according to BMI, physical activity and parental overweight/obesity and type 2 diabetes. Brain, skeletal muscle, brown adipose tissue (BAT), visceral adipose tissue (VAT) and abdominal and femoral s.c. adipose tissue (SAT) glucose uptake (GU) rates were measured. Endogenous glucose production (EGP) was calculated by subtracting the exogenous glucose infusion rate from the rate of disappearance of [18F]FDG. BGU was analyzed using statistical parametric mapping, and peripheral tissue activity was determined using Carimas Software imaging processing platform.
BGU was higher in the HR vs LR group and correlated inversely with whole-body insulin sensitivity (M value) in the HR group but not in the LR group. Insulin-suppressed EGP did not differ between the groups but correlated positively with BGU in the whole population, and the correlation was driven by the HR group. Skeletal muscle, BAT, VAT, abdominal and femoral SAT GU were lower in the HR group as compared to the LR group. Muscle GU correlated negatively with BGU in the HR group but not in the LR group.
Increased BGU, alterations in insulin action in the brain-liver axis and decreased whole-body insulin sensitivity occur early in pre-obese state.
探讨肥胖前期的年轻人群中，脑葡萄糖摄取（BGU）、脑-肝轴胰岛素作用和全身胰岛素敏感性是否发生改变。
研究纳入高肥胖风险（HR；n=19）和低肥胖风险（LR；n=22）的健康男性，采用[18F]氟代葡萄糖（[18F]FDG）-正电子发射断层扫描（PET），在高胰岛素-正常血糖钳夹状态下进行。肥胖风险根据 BMI、体力活动和父母超重/肥胖及 2 型糖尿病进行评估。测量脑、骨骼肌、棕色脂肪组织（BAT）、内脏脂肪组织（VAT）和腹部及股部皮下脂肪组织（SAT）的葡萄糖摄取（GU）率。通过从[18F]FDG 的清除率中减去外源性葡萄糖输注率来计算内源性葡萄糖生成（EGP）。使用统计参数映射分析 BGU，使用 Carimas 软件成像处理平台来确定外周组织活性。
HR 组的 BGU 高于 LR 组，与 HR 组的全身胰岛素敏感性（M 值）呈负相关，但在 LR 组中无相关性。两组之间的胰岛素抑制 EGP 无差异，但在整个研究人群中与 BGU 呈正相关，且相关性由 HR 组驱动。与 LR 组相比，HR 组的骨骼肌、BAT、VAT、腹部和股部 SAT 的 GU 较低。HR 组的肌肉 GU 与 BGU 呈负相关，但在 LR 组中无相关性。
肥胖前期就会出现 BGU 增加、脑-肝轴胰岛素作用改变和全身胰岛素敏感性降低。
