Dept of Chemistry, University of Reading, Whiteknights, Reading RG6 6AD, UK.
Chem Commun (Camb). 2010 Sep 14;46(34):6270-2. doi: 10.1039/c0cc00212g. Epub 2010 Jul 29.
The structure of single wall peptide nanotubes is presented for the model surfactant-like peptide A(6)K. Capillary flow alignment of a sample in the nematic phase at high concentration in water leads to oriented X-ray diffraction patterns. Analysis of these, accompanied by molecular dynamics simulations, suggests the favourable self-assembly of antiparallel peptide dimers into beta-sheet ribbons that wrap helically to form the nanotube wall.
呈现了模型表面活性剂样肽 A(6)K 的单壁肽纳米管结构。在水中高浓度的向列相样品中的毛细流动排列导致了取向的 X 射线衍射图案。对这些图案的分析，伴随着分子动力学模拟，表明了反平行肽二聚体有利于自组装成β-折叠带，这些折叠带螺旋缠绕形成纳米管壁。
