Zea M, Bermejo P E, Carrillo F
Hospital del Henares, Coslada, Madrid, Espana.
Rev Neurol. 2010 Sep 1;51(5):295-301.
The fibrinolytic system, also named plasminogen system is formed by a group of molecules that transforms plasminogen in its active form plasmine, which is able to participate in a number of pathophysiological processes.
To carry out a review of the literature and an analysis of the relationship between fibrinolytic system and neurological diseases and its potential therapeutic implications.
The fibrinolytic system has been involved in many different pathologies. Although its role in neurological diseases has always been thought to be scarce, many relations have been recently established. This way, fibrinolytic system seems to be involved not only in cerebrovascular diseases but also in epilepsy, inflammatory diseases such as multiple sclerosis, alterations of the dopaminergic system, learning disorders and several lesions of the peripheral nervous system. Different genotypes of several components of this system have been related as risk or protector factors to the development of these neurological diseases and information to this respect is rapidly increasing.
A better knowledge about the relations between the fibrinolytic system and neurological diseases could clarify several aspects about their pathophysiology and it could suppose future prevention and treatment lines.
纤维蛋白溶解系统，也称为纤溶酶原系统，由一组分子组成，这些分子将纤溶酶原转化为其活性形式纤溶酶，纤溶酶能够参与许多病理生理过程。
对文献进行综述，并分析纤维蛋白溶解系统与神经疾病之间的关系及其潜在的治疗意义。
纤维蛋白溶解系统已涉及许多不同的病理状况。尽管一直认为其在神经疾病中的作用很小，但最近已建立了许多联系。这样，纤维蛋白溶解系统似乎不仅参与脑血管疾病，还参与癫痫、诸如多发性硬化症等炎症性疾病、多巴胺能系统的改变、学习障碍以及周围神经系统的几种病变。该系统几个组分的不同基因型已被认为是这些神经疾病发生发展的风险或保护因素，并且这方面的信息正在迅速增加。
更好地了解纤维蛋白溶解系统与神经疾病之间的关系可以阐明其病理生理学的几个方面，并可能为未来的预防和治疗提供思路。
