Department of Pathology and Laboratory Medicine, University of Texas-Houston Medical School, Houston, TX 77030, USA.
Arch Pathol Lab Med. 2010 Aug;134(8):1188-92. doi: 10.5858/2009-0404-OA.1.
Hawthorn is an herb indicated for treating cardiac illness. Because a patient taking digoxin may also take hawthorn, we investigated potential interference of hawthorn in serum digoxin measurements using immunoassays as well as pharmacodynamic interaction between hawthorn and digoxin. Hawthorn contains alkaloids that are structurally similar to digoxin and may interfere with serum digoxin measurement using immunoassays. In addition, hawthorn has cardioactive properties similar to digoxin.
To study potential pharmacodynamic interaction between hawthorn and digoxin.
The effects of hawthorn extract on serum digoxin measurements using Digoxin III (Abbott Laboratories, Abbott Park, Illinois) and the Tina-Quant digoxin assay (Roche Diagnostics, Indianapolis, Indiana) were investigated using 2 different brands of extract. To study the pharmacodynamic interaction between hawthorn and digoxin, we used an isolated adult rat cardiomyocyte system, measuring calcium transients by real-time fluorescence spectrophotometry.
Hawthorn interfered only with the Digoxin III immunoassay but had no effect on the Tina-Quant assay. Both hawthorn extracts increased intracellular calcium levels, but the lack of additive response with digoxin suggests both may bind to the same site of Na, K adenosine triphosphatase.
Because of interference of hawthorn with a digoxin immunoassay and pharmacodynamic interaction with digoxin, a patient receiving digoxin should avoid hawthorn.
山楂是一种用于治疗心脏疾病的草药。由于服用地高辛的患者也可能同时服用山楂，我们研究了山楂对免疫测定法检测血清地高辛的潜在干扰作用，以及山楂与地高辛之间的药效学相互作用。山楂含有与地高辛结构相似的生物碱，可能会干扰免疫测定法检测血清地高辛。此外，山楂具有与地高辛相似的心脏活性。
研究山楂与地高辛之间的潜在药效学相互作用。
使用两种不同品牌的提取物研究山楂提取物对 Abbott Laboratories（伊利诺伊州雅培公园）的 Digoxin III 和 Roche Diagnostics（印第安纳波利斯，印第安纳州）的 Tina-Quant 地高辛检测试剂盒检测血清地高辛的影响。为了研究山楂与地高辛之间的药效学相互作用，我们使用了分离的成年大鼠心肌细胞系统，通过实时荧光分光光度法测量钙瞬变。
山楂仅与 Digoxin III 免疫测定法相互作用，但对 Tina-Quant 检测试剂盒没有影响。两种山楂提取物均增加了细胞内钙水平，但与地高辛无附加反应表明两者可能与 Na、K 三磷酸腺苷酶的相同部位结合。
由于山楂对地高辛免疫测定法的干扰以及与地高辛的药效学相互作用，服用地高辛的患者应避免服用山楂。
