Department of Surgery, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Crit Rev Microbiol. 2010 Nov;36(4):340-8. doi: 10.3109/1040841X.2010.495941.
As the genomics era matures, the availability of complete microbial genome sequences is facilitating computational approaches to understand bacterial genomes and DNA structure/function relationships. From the genome of pathogens, we can derive invaluable information on potential targets for new antimicrobial agents. Advancements in high-throughput 'omics' technologies and the availability of multiple isolates of the same species have significantly changed the time frame and scope for identifying novel therapeutic targets. This article aims to discuss selected aspects of the bacterial genome, and advocates 'omics'-based techniques to advance the discovery of new therapeutic targets against extracellular bacterial pathogens.
随着基因组时代的成熟，完整的微生物基因组序列的可用性正在促进计算方法的发展，以帮助我们理解细菌基因组和 DNA 结构/功能关系。从病原体的基因组中，我们可以获得有关新抗菌药物潜在靶标的宝贵信息。高通量“组学”技术的进步和同一物种的多个分离株的可用性，极大地改变了识别新型治疗靶标的时间框架和范围。本文旨在讨论细菌基因组的一些选定方面，并提倡基于“组学”的技术来推进针对细胞外细菌病原体的新型治疗靶标的发现。
