Johnson Benjamin K, Abramovitch Robert B
Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI 48824, USA.
Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI 48824, USA.
Trends Pharmacol Sci. 2017 Apr;38(4):339-362. doi: 10.1016/j.tips.2017.01.004. Epub 2017 Feb 14.
The continued rise of antibiotic-resistant bacterial infections has motivated alternative strategies for target discovery and treatment of infections. Antivirulence therapies function through inhibition of in vivo required virulence factors to disarm the pathogen instead of directly targeting viability or growth. This approach to treating bacteria-mediated diseases may have advantages over traditional antibiotics because it targets factors specific for pathogenesis, potentially reducing selection for resistance and limiting collateral damage to the resident microbiota. This review examines vulnerable molecular mechanisms used by bacteria to cause disease and the antivirulence compounds that sabotage these virulence pathways. By expanding the study of antimicrobial targets beyond those that are essential for growth, antivirulence strategies offer new and innovative opportunities to combat infectious diseases.
抗生素耐药性细菌感染的持续增加促使人们寻找用于感染靶点发现和治疗的替代策略。抗毒力疗法通过抑制体内所需的毒力因子来使病原体失去致病性，而不是直接针对其生存能力或生长。这种治疗细菌介导疾病的方法可能比传统抗生素具有优势，因为它针对的是发病机制特有的因子，有可能减少耐药性的产生并限制对常驻微生物群的附带损害。本综述探讨了细菌用于致病的脆弱分子机制以及破坏这些毒力途径的抗毒力化合物。通过将抗菌靶点的研究扩展到生长所必需的靶点之外，抗毒力策略为对抗传染病提供了新的创新机会。
