血管内皮生长因子基因单核苷酸多态性与系统性红斑狼疮及狼疮性肾炎的相关性。
The association of single nucleotide polymorphism within vascular endothelial growth factor gene with systemic lupus erythematosus and lupus nephritis.
机构信息
Lupus Research Unit, Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
出版信息
Int J Immunogenet. 2011 Feb;38(1):63-7. doi: 10.1111/j.1744-313X.2010.00960.x.
Abstract
There were no statistically significant difference in allele and genotype frequency of the polymorphisms within the vascular endothelial growth factor (VEGF) gene (-460 and +405) between 193 systemic lupus erythematosus patients and 234 healthy controls. However, the +405 GG was significantly associated with lupus nephritis (LN) patients with low VEGF mRNA expression and LN with end-stage renal disease.
摘要
在 193 例系统性红斑狼疮患者和 234 例健康对照者中，血管内皮生长因子（VEGF）基因（-460 和+405）的多态性在等位基因和基因型频率方面无统计学差异。然而，+405 GG 与 VEGF mRNA 表达水平低的狼疮肾炎（LN）患者和终末期肾病的 LN 显著相关。
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