Wei Ni, Chen Zijia, Xue Zhifeng, Zhu Yuelan
Department of Rheumatism, DongFang Hospital of BeiJing University of Chinese Medicine, Fang Zhuang, Fang Xing District 1, No. Six, Fengtai District, Beijing, 100078, China.
Rheumatol Int. 2015 Aug;35(8):1351-60. doi: 10.1007/s00296-015-3279-0. Epub 2015 May 26.
Background Vascular endothelial growth factor (VEGF) is an important angiogenic factor and may be connected with chronic immune-mediated inflammatory diseases (IMIDs) to some extent. However, previous researches about the relationship between the +405G>C (dbSNP: rs2010963) polymorphism in VEGF gene and the risk of IMIDs are controversial and inconsistent. So we conducted this meta-analysis to assess whether the relationship between the +405G>C polymorphism in the 5'-UTR region of VEGF gene and IMID susceptibility exists. Methods Our literature search was conducted on the PubMed, Embase, Web of science, Chinese National Knowledge Infrastructure, and Chinese Biomedical databases to retrieve for eligible studies. Odds ratios as well as their 95 % confidence intervals were utilized to deduce the possible relationship. Results A total number of 5175 patients with IMIDs and 7069 healthy controls from 27 case-control studies were included. For the overall eligible data collected in our meta-analysis, there was no marked relationship between +405G>C polymorphism and the risk of IMIDs. However, subgroup analysis by ethnicity suggested that +405C allele could be a protective factor for IMIDs in Asians, whereas an opposite conclusion was drawn in Caucasians. Conclusion Thus, we may come to the conclusion that the VEGF +405G>C polymorphism could be associated with IMIDs, and the correlation might vary with ethnic groups.
背景 血管内皮生长因子（VEGF）是一种重要的血管生成因子，在一定程度上可能与慢性免疫介导的炎症性疾病（IMIDs）相关。然而，先前关于VEGF基因中+405G>C（dbSNP：rs2010963）多态性与IMIDs风险之间关系的研究存在争议且不一致。因此，我们进行了这项荟萃分析，以评估VEGF基因5'-UTR区域的+405G>C多态性与IMID易感性之间是否存在关联。方法 我们在PubMed、Embase、Web of science、中国知网和中国生物医学数据库中进行文献检索，以检索符合条件的研究。利用比值比及其95%置信区间来推断可能的关系。结果 纳入了来自27项病例对照研究的总共5175例IMIDs患者和7069例健康对照。对于我们荟萃分析中收集的总体合格数据，+405G>C多态性与IMIDs风险之间没有显著关系。然而，按种族进行的亚组分析表明，+405C等位基因可能是亚洲人IMIDs的保护因素，而在白种人中得出了相反的结论。结论 因此，我们可以得出结论，VEGF +405G>C多态性可能与IMIDs相关，且这种相关性可能因种族而异。
