Jones J M, Jensen F, Feldman J D
J Natl Cancer Inst. 1978 Jun;60(6):1467-72. doi: 10.1093/jnci/60.6.1467.
When BN and LEW rats were immunized with untreated or with inactivated Moloney murine leukemia virus (M-MuLV), BN rats produced high antibody responses to the p15, p30, and gp70 antigens of the virus, whereas LEW rats were low responders to these antigens. BN rats also exhibited a high response and LEW rats a low response when the two strains were immunized with purified p30. Studies of (LEW X BN)F1 and backcross rats suggested that factors associated with AgB exerted major influences on responses to antigens of M-MuLV and that other factors were also important. When other rat strains representing 5 AgB alleles were tested, some were high and some were low responders to M-MuLV, and responses to p15, p30, and gp70 were not always parallel. Since M-MuLV replication was greater in cells of BN rats than in cells of LEW rats, replication of M-MuLV may have influenced the levels of responses to some viral antigens. Control of virus replication appeared to be due to cell mechanisms rather than to the environment of the host.
当用未处理的或灭活的莫洛尼鼠白血病病毒（M-MuLV）对BN大鼠和LEW大鼠进行免疫时，BN大鼠对该病毒的p15、p30和gp70抗原产生高抗体反应，而LEW大鼠对这些抗原反应较弱。当用纯化的p30对这两种品系的大鼠进行免疫时，BN大鼠也表现出高反应，而LEW大鼠反应较低。对（LEW×BN）F1代大鼠和回交大鼠的研究表明，与AgB相关的因素对M-MuLV抗原的反应有主要影响，其他因素也很重要。当测试代表5个AgB等位基因的其他大鼠品系时，一些对M-MuLV反应高，一些反应低，并且对p15、p30和gp70的反应并不总是平行的。由于M-MuLV在BN大鼠细胞中的复制比在LEW大鼠细胞中更活跃，M-MuLV的复制可能影响了对某些病毒抗原的反应水平。病毒复制的控制似乎是由于细胞机制而非宿主环境。
