小鼠白血病病毒克隆分离株的致白血病性
Leukemogenicity of clonal isolates of murine leukemia viruses.
作者信息
Jolicoeur P, Rosenberg N, Cotellessa A, Baltimore D
出版信息
J Natl Cancer Inst. 1978 Jun;60(6):1473-6. doi: 10.1093/jnci/60.6.1473.
PMID:206713
Abstract
The leukemogenicity of three types of cloned, in vitro grown murine retroviruses was studied. Two Moloney virus clones caused leukemia, as did five clones of the B-tropic endogenous virus of BALB/c mice. Neither of two clones of N-tropic BALB/c virus caused leukemia in Fv-1n/n mice, and the viruses were not recoverable from the animals. The ability to induce leukemia therefore appeared to reside in the genome of at least certain nondefective murine retroviruses.
摘要
研究了三种克隆的、体外培养的鼠逆转录病毒的致白血病性。两个莫洛尼病毒克隆引发了白血病，BALB/c小鼠的B嗜性内源性病毒的五个克隆也引发了白血病。N嗜性BALB/c病毒的两个克隆在Fv-1n/n小鼠中均未引发白血病，并且无法从这些动物体内分离出病毒。因此，诱导白血病的能力似乎至少存在于某些无缺陷的鼠逆转录病毒的基因组中。
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