Odaka T
J Virol. 1975 Feb;15(2):332-7. doi: 10.1128/JVI.15.2.332-337.1975.
Spontaneous expression of endogenous N- and B-tropic murine leukemia viruses was stu1bb), DDD (Fuv-1nn), DDD-Fvr (fv-1nn), (DDD or DDD-Fvr times C57BL/6)F1, and 16 partially inbredlines with either the Fv-1nn or Fv-1bb genotype, which had been established from hybrids between C57BL/6 and DDD-Fvr. When tested at middle age, virus-positive mice were found in C57BL/6, F1 hybrids, and 9 out of 16 partially inbred lines. N-tropic viruses were isolated from Fv-1nn, Fv-1bb mice, whereas B-tropic viruses, except for one isolate, were from Fv-1bb mice only. C57BL/6 mice were positive for both N- and B-tropic viruses, whereas DDD-Fvr mice were negative. With respect to the Fv-1 genotype and the presence of endogenous murine leukemia viruses, the partially inbred lines were grouped into five types: (i) Fv-1bb, both N- and B-tropic virus positive, like C57BL/6; (ii) Fv-1nn, virus negative, like DDD-Fvr; (iii) Fv-1bb, virus negative; (iv) Fv-1nn, only N-tropic virus positive; and (v) less convincingly, Fv-1bb, only B-tropic virus positive. These findings indicate that the transmission of N- and B-tropic viruses in C57BL/6 is genetically controlled and that the expression of B-tropic virus, but not of N-tropic virus, is closely associated with the Fv-1 genotype.
对内源性N型和B型嗜性鼠白血病病毒的自发表达进行了研究，实验对象包括：C57BL/6、DDD（Fuv-1nn）、DDD-Fvr（fv-1nn）、（DDD或DDD-Fvr与C57BL/6杂交的）F1代，以及16个具有Fv-1nn或Fv-1bb基因型的部分近交系，这些近交系是由C57BL/6与DDD-Fvr的杂交后代培育而成。在中年期进行检测时，发现C57BL/6、F1代杂种以及16个部分近交系中的9个存在病毒阳性小鼠。从Fv-1nn、Fv-1bb小鼠中分离出了N型嗜性病毒，而除了一个分离株外，B型嗜性病毒仅从Fv-1bb小鼠中分离得到。C57BL/6小鼠同时感染了N型和B型嗜性病毒，而DDD-Fvr小鼠呈阴性。就Fv-1基因型和内源性鼠白血病病毒的存在情况而言，部分近交系可分为五种类型：（i）Fv-1bb，N型和B型嗜性病毒均呈阳性，与C57BL/6类似；（ii）Fv-1nn，病毒阴性，与DDD-Fvr类似；（iii）Fv-1bb，病毒阴性；（iv）Fv-1nn，仅N型嗜性病毒呈阳性；（v）不太确定，Fv-1bb，仅B型嗜性病毒呈阳性。这些发现表明，C57BL/6中N型和B型嗜性病毒的传播受遗传控制，且B型嗜性病毒的表达而非N型嗜性病毒的表达与Fv-1基因型密切相关。
