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The protective effects of (4R)-hexahydro-7,7-dimethyl-6-oxo-1,2,5-dithiazocine-4-carboxylic acid (SA3443), a novel cyclic disulfide, on chemically-induced acute liver injury.

作者信息

Ishida N, Nakata K, Tanaka M, Takase K, Mita S

机构信息

Central Research Laboratories, Santen Pharmaceutical Co., Ltd., Osaka, Japan.

出版信息

Jpn J Pharmacol. 1991 Feb;55(2):275-8. doi: 10.1254/jjp.55.275.

DOI:10.1254/jjp.55.275
PMID:2067142
Abstract

The effects of SA3443, a novel cyclic disulfide compound, on acute liver injuries induced by carbon tetrachloride (CCl4), D-galactosamine and DL-ethionine were studied in rats or mice. SA3443 (100-300 mg/kg, p.o.) significantly suppressed the increases of serum transaminase activity and liver triglyceride content in the CCl4 or DL-ethionine-induced model. Furthermore, SA3443 (300 mg/kg, p.o.) clearly reduced the formation of hepatic lipid peroxide in CCl4-treated rats. These results indicate that SA3443 protects the liver against acute liver injury.

摘要

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