新型环状二硫化物化合物SA3443对大鼠α-萘基异硫氰酸酯诱导的肝内胆汁淤积的抑制作用。

The inhibitory effect of SA3443, a novel cyclic disulfide compound, on alpha-naphthyl isothiocyanate-induced intrahepatic cholestasis in rats.

Tanaka M, Nakata K, Mita S

Central Research Laboratories, Santen Pharmaceutical Co. Ltd, Osaka, Japan.

Clin Exp Pharmacol Physiol. 1993 Sep;20(9):543-7. doi: 10.1111/j.1440-1681.1993.tb01739.x.

Abstract

We investigated the effect of SA3443, a novel cyclic disulfide compound, on alpha-naphthyl isothiocyanate (ANIT)-induced intrahepatic cholestasis in rats. 2. SA3443 given orally at doses of 100 or 300 mg/kg, three times at 4h intervals, dose-dependently suppressed the elevation of serum total bilirubin, alkaline phosphatase activity and transaminase activities induced by administration of ANIT (80 mg/kg) 3h before the second dosages of SA3443. 3. SA3443 also significantly inhibited the reduction of bile flow in the ANIT-treated rats. 4. These findings indicated that SA3443 had a markedly inhibitory effect on ANIT-induced intrahepatic cholestasis in rats.

摘要

我们研究了新型环状二硫化物化合物SA3443对大鼠α-萘异硫氰酸酯（ANIT）诱导的肝内胆汁淤积的影响。2. 在第二次给予SA3443前3小时给予ANIT（80mg/kg），之后以100或300mg/kg的剂量口服SA3443，每隔4小时给药3次，SA3443剂量依赖性地抑制了血清总胆红素、碱性磷酸酶活性以及转氨酶活性的升高。3. SA3443还显著抑制了ANIT处理的大鼠胆汁流量的减少。4. 这些发现表明SA3443对大鼠ANIT诱导的肝内胆汁淤积具有明显的抑制作用。