手性 (R,R)-TADDOL 亚膦酸酯对亚胺的高非对映选择性氢膦酰化反应. 手性 α-氨基膦酸酯衍生物的不对称合成.

Diastereoselective hydrophosphonylation of imines using (R,R)-TADDOL phosphite. Asymmetric synthesis of alpha-aminophosphonic acid derivatives.

机构信息

Departamento de Química Orgánica I, Facultad de Farmacia, Universidad del País Vasco, Apartado 450, 01080 Vitoria, Spain.

出版信息

Org Biomol Chem. 2010 Oct 7;8(19):4255-8. doi: 10.1039/c003004j. Epub 2010 Jul 29.

DOI:10.1039/c003004j

PMID:20672154

Abstract

Efficient synthesis of alpha-aminophosphonic acid derivatives is achieved, the key step being a diastereoselective hydrophosphonylation of N-diphenylphosphinyl imines using a readily available chiral cyclic (R,R)-TADDOL-phosphite derived from inexpensive natural tartaric acid.

摘要

高效合成了 α-氨基膦酸衍生物，关键步骤是使用易得的、由廉价天然酒石酸衍生的手性环状（R,R）-TADDOL-亚磷酸酯对 N-二苯膦酰亚胺进行非对映选择性氢膦化反应。