Boillat Carol S, Gaschen Frédéric P, Gaschen Lorrie, Stout Rhett W, Hosgood Giselle L
Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803, USA.
Am J Vet Res. 2010 Aug;71(8):903-8. doi: 10.2460/ajvr.71.8.903.
To compare repeatability of measurements of gastrointestinal tract motility in healthy dogs obtained by use of a wireless motility capsule (WMC) and scintigraphy.
6 healthy adult dogs (mean +/- SD body weight, 21.5 +/- 1.8 kg).
A radiolabeled test meal was offered immediately after oral administration of a WMC. Serial static scintigraphic abdominal images were acquired for 270 minutes. A dedicated remote receiver was used for data collection from the WMC until the WMC was expelled in the feces. Each dog was evaluated 3 times at intervals of 1 to 2 weeks.
Mean gastric emptying half-time measured by use of scintigraphy (T(1/2)-GES) for each dog ranged from 99.9 to 181.2 minutes. Mean gastric emptying time (GET) measured by use of the WMC (GET-WMC) in each dog ranged from 385.3 to 669.7 minutes. Mean coefficient of variation was 11.8% for T(1/2)-GES and 7.8% for GET-WMC. The intraclass correlation coefficient was 69% for T(1/2)-GES and 71% for GET-WMC. Results for a nested analysis of covariance suggested that both methods were comparable for the evaluation of gastric emptying.
Scintigraphy and a WMC system had similar variation for assessment of gastric emptying. Moderate intraindividual variability was detected for both methods and must be considered when interpreting test results for individual dogs. Repeatability of measurements obtained by use of the WMC was equivalent to that obtained by use of scintigraphy. The WMC system offers a nonradioactive, user-friendly method for assessment of gastric emptying in dogs.
比较使用无线动力胶囊（WMC）和闪烁扫描法对健康犬胃肠道动力测量的重复性。
6只健康成年犬（平均体重±标准差，21.5±1.8千克）。
口服WMC后立即给予放射性标记测试餐。连续采集270分钟的腹部静态闪烁扫描图像。使用专用远程接收器从WMC收集数据，直至WMC随粪便排出。每只犬每隔1至2周评估3次。
每只犬使用闪烁扫描法测得的平均胃排空半衰期（T(1/2)-GES）为99.9至181.2分钟。每只犬使用WMC测得的平均胃排空时间（GET-WMC）为385.3至669.7分钟。T(1/2)-GES的平均变异系数为11.8%，GET-WMC的平均变异系数为7.8%。组内相关系数T(1/2)-GES为69%，GET-WMC为71%。协方差嵌套分析结果表明，两种方法在评估胃排空方面具有可比性。
闪烁扫描法和WMC系统在评估胃排空方面具有相似的变异性。两种方法均检测到中度个体内变异性，在解释个体犬的测试结果时必须予以考虑。使用WMC获得的测量重复性与使用闪烁扫描法相当。WMC系统为评估犬胃排空提供了一种无放射性、用户友好的方法。
