Department of Orthopaedics and Traumatology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.
Scand J Med Sci Sports. 2011 Feb;21(1):3-17. doi: 10.1111/j.1600-0838.2010.01164.x.
Chronic tendinopathy refers to a broad spectrum of pathological conditions in tendons and their insertion, with symptoms including activity-related chronic pain. To study the pathogenesis and management strategies of chronic tendinopathy, studies in animal models are essential. The different animal models in the literature present advantages and limitations, and there is no consensus regarding the criteria of a universal tendinopathy animal model. Based on the review of literature and the discussion in the International Symposium on Ligaments and Tendons-X, we concluded that established clinical, histopathological and functional characteristics of human tendinopathy were all important and relevant criteria to be met, if possible, by animal models. As tendinopathy is a progressive, multifactorial tendon disorder affecting different anatomical structures, it may not be realistic to expect a single animal model to study all aspects of tendinopathy. Staging of tendinopathy over time and clearer definition of tendinopathies in relation to severity and type would enable realistic targets with any animal model. The existing animal models can be used for answering specific questions (horses for courses) but should not be used to conclude the general aspects of tendinopathy neither in animals nor in human.
慢性肌腱病是指肌腱及其附着处的广泛病理状况，其症状包括与活动相关的慢性疼痛。为了研究慢性肌腱病的发病机制和管理策略，动物模型的研究至关重要。文献中的不同动物模型具有各自的优缺点，目前尚无关于通用肌腱病动物模型标准的共识。基于文献回顾和 Ligaments and Tendons-X 国际研讨会的讨论，我们得出结论，如果可能的话，动物模型应符合人类肌腱病的既定临床、组织病理学和功能特征等重要相关标准。由于肌腱病是一种影响不同解剖结构的渐进性、多因素的肌腱疾病，因此可能不太现实地期望单一动物模型能够研究肌腱病的所有方面。随着时间的推移对肌腱病进行分期，以及更明确地定义与严重程度和类型相关的肌腱病，将能够为任何动物模型设定更现实的目标。现有的动物模型可用于回答特定问题（具体问题具体分析），但不应将其用于在动物或人类中推断肌腱病的一般方面。
