通过前列腺特异性抗原追踪肿瘤演变：一项个体术后研究。
Tracking tumor evolution via prostate-specific antigen: an individual post-operative study.
作者信息
Erbudak Mehmet, Erzan Ayşe
机构信息
Laboratory for Solid State Physics, ETH Zurich, CH-8093 Zurich, Switzerland.
出版信息
Theor Biol Med Model. 2010 Jul 30;7:30. doi: 10.1186/1742-4682-7-30.
BACKGROUND
The progress of the prostate-specific antigen (PSA) level after radical prostatectomy is observed for a patient in order to extract information about the mode of tumor cell growth. Although PSA values are determined routinely to find the doubling time of the prostate marker, to our knowledge, this analysis is the first in the literature.
RESULTS
The prostate tumor marker values were determined regularly after the surgery and plotted on a logarithmic scale against time. An initial rapid-growth mode changed to a slower power-law regime within two years of surgery. Our analysis associates this observation with a transition in the growth mode from unrestricted growth of dispersed cells to their clumping into macroscopic structures.
CONCLUSIONS
Such studies may help determine the appropriate time window for postoperative therapies in order to increase the life expectancy of the patient.
背景
为了获取有关肿瘤细胞生长模式的信息，对一名患者根治性前列腺切除术后前列腺特异性抗原（PSA）水平的变化进行了观察。尽管通常会测定PSA值以确定前列腺标志物的倍增时间，但据我们所知，该分析是文献中的首例。
结果
术后定期测定前列腺肿瘤标志物值，并以对数尺度对时间作图。术后两年内，初始的快速生长模式转变为较慢的幂律状态。我们的分析将这一观察结果与生长模式从分散细胞的无限制生长转变为聚集成宏观结构联系起来。
结论
此类研究可能有助于确定术后治疗的合适时间窗，以提高患者的预期寿命。
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