Guiot Caterina, Degiorgis Piero Giorgio, Delsanto Pier Paolo, Gabriele Pietro, Deisboeck Thomas S
Dip. Neuroscience, Universita di Torino, C. Raffaello 30, 10125, Torino, Italy.
J Theor Biol. 2003 Nov 21;225(2):147-51. doi: 10.1016/s0022-5193(03)00221-2.
A general model for the ontogenetic growth of living organisms has been recently proposed. Here we investigate the extension of this model to the growth of solid malignant tumors. A variety of in vitro and in vivo data are analysed and compared with the prediction of a "universal" law, relating properly rescaled tumor masses and tumor growth times. The results support the notion that tumor growth follows such a universal law. Several important implications of this finding are discussed, including its relevance for tumor metastasis and recurrence, cell turnover rates, angiogenesis and invasion.
最近提出了一种关于生物体个体发育生长的通用模型。在此，我们研究该模型对实体恶性肿瘤生长的扩展。分析了各种体外和体内数据，并与一个“通用”定律的预测进行比较，该定律将适当重新缩放的肿瘤质量与肿瘤生长时间联系起来。结果支持肿瘤生长遵循这种通用定律的观点。讨论了这一发现的几个重要意义，包括其与肿瘤转移和复发、细胞更新率、血管生成和侵袭的相关性。
